FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897974793> ?p ?o ?g. }

• W2897974793 endingPage "19316" @default.
• W2897974793 startingPage "19303" @default.
• W2897974793 abstract "Functional up-regulation of heat shock factor 1 (HSF1) activity through different posttranslational modifications has been implicated in the survival and proliferation of various cancers. It is increasingly recognized that the HSF1 gene is also up-regulated at the transcriptional level, a phenomenon correlated with poor prognosis for patients with different cancers, including breast cancer. Here, we analyzed the transcriptional up-regulation of HSF1 in human cells upon arsenite- or peroxide-induced oxidative stress. Sequential promoter truncation coupled with bioinformatics analysis revealed that this activation is mediated by two antioxidant response elements (AREs) located between 1707 and 1530 bp upstream of the transcription start site of the HSF1 gene. Using shRNA-mediated down-regulation, ChIP of NRF2, site-directed mutagenesis of the AREs, and DNase I footprinting of the HSF1 promoter, we confirmed that nuclear factor erythroid-derived 2-like 2 (NRF2, also known as NFE2L2) interacts with these AREs and up-regulates HSF1 expression. We also found that BRM/SWI2-related gene 1 (BRG1), a catalytic subunit of SWI2/SNF2-like chromatin remodeler, is involved in this process. We further show that NRF2-dependent HSF1 gene regulation plays a crucial role in cancer cell biology, as interference with NRF2-mediated HSF1 activation compromised survival, migration potential, and the epithelial-to-mesenchymal transition and autophagy in MCF7 breast cancer cells exposed to oxidative stress. Taken together, our findings unravel the mechanistic basis of HSF1 gene regulation in cancer cells and provide molecular evidence supporting a direct interaction between HSF1 and NRF2, critical regulators of two cytoprotective mechanisms exploited by cancer cells." @default.
• W2897974793 created "2018-10-26" @default.
• W2897974793 creator A5013322398 @default.
• W2897974793 creator A5020360606 @default.
• W2897974793 creator A5041161409 @default.
• W2897974793 creator A5050463530 @default.
• W2897974793 creator A5057820435 @default.
• W2897974793 date "2018-12-01" @default.
• W2897974793 modified "2023-10-17" @default.
• W2897974793 title "NRF2 transcriptionally activates the heat shock factor 1 promoter under oxidative stress and affects survival and migration potential of MCF7 cells" @default.
• W2897974793 cites W1065982923 @default.
• W2897974793 cites W126188432 @default.
• W2897974793 cites W1421415727 @default.
• W2897974793 cites W1789875395 @default.
• W2897974793 cites W1874817816 @default.
• W2897974793 cites W1917529770 @default.
• W2897974793 cites W1964464338 @default.
• W2897974793 cites W1966830269 @default.
• W2897974793 cites W1967138582 @default.
• W2897974793 cites W1972088490 @default.
• W2897974793 cites W1974546855 @default.
• W2897974793 cites W1990598806 @default.
• W2897974793 cites W1991005777 @default.
• W2897974793 cites W1992724001 @default.
• W2897974793 cites W1993069510 @default.
• W2897974793 cites W1997767982 @default.
• W2897974793 cites W1998560601 @default.
• W2897974793 cites W1999872962 @default.
• W2897974793 cites W2004232360 @default.
• W2897974793 cites W2009761723 @default.
• W2897974793 cites W2014691022 @default.
• W2897974793 cites W2020240443 @default.
• W2897974793 cites W2022501802 @default.
• W2897974793 cites W2023598683 @default.
• W2897974793 cites W2035676834 @default.
• W2897974793 cites W2039403501 @default.
• W2897974793 cites W2042891907 @default.
• W2897974793 cites W2045494987 @default.
• W2897974793 cites W2053119214 @default.
• W2897974793 cites W2054307404 @default.
• W2897974793 cites W2066688007 @default.
• W2897974793 cites W2071960601 @default.
• W2897974793 cites W2076486765 @default.
• W2897974793 cites W2086818085 @default.
• W2897974793 cites W2097419756 @default.
• W2897974793 cites W2101121084 @default.
• W2897974793 cites W2102042089 @default.
• W2897974793 cites W2104976381 @default.
• W2897974793 cites W2107277218 @default.
• W2897974793 cites W2121565438 @default.
• W2897974793 cites W2126793001 @default.
• W2897974793 cites W2138625851 @default.
• W2897974793 cites W2139560472 @default.
• W2897974793 cites W2140452134 @default.
• W2897974793 cites W2143693669 @default.
• W2897974793 cites W2146558971 @default.
• W2897974793 cites W2149593386 @default.
• W2897974793 cites W2151614363 @default.
• W2897974793 cites W2152175948 @default.
• W2897974793 cites W2152231829 @default.
• W2897974793 cites W2152622809 @default.
• W2897974793 cites W2157360354 @default.
• W2897974793 cites W2159294242 @default.
• W2897974793 cites W2160167196 @default.
• W2897974793 cites W2165113979 @default.
• W2897974793 cites W2165167356 @default.
• W2897974793 cites W2221163883 @default.
• W2897974793 cites W2322809234 @default.
• W2897974793 cites W2326884456 @default.
• W2897974793 cites W2415945663 @default.
• W2897974793 cites W2528899297 @default.
• W2897974793 cites W2542340122 @default.
• W2897974793 cites W2560443178 @default.
• W2897974793 cites W2571999091 @default.
• W2897974793 cites W2611475096 @default.
• W2897974793 cites W2621333085 @default.
• W2897974793 cites W2751896753 @default.
• W2897974793 cites W2801988573 @default.
• W2897974793 cites W780734366 @default.
• W2897974793 cites W952491933 @default.
• W2897974793 doi "https://doi.org/10.1074/jbc.ra118.003376" @default.
• W2897974793 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6302185" @default.
• W2897974793 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30309986" @default.
• W2897974793 hasPublicationYear "2018" @default.
• W2897974793 type Work @default.
• W2897974793 sameAs 2897974793 @default.
• W2897974793 citedByCount "42" @default.
• W2897974793 countsByYear W28979747932019 @default.
• W2897974793 countsByYear W28979747932020 @default.
• W2897974793 countsByYear W28979747932021 @default.
• W2897974793 countsByYear W28979747932022 @default.
• W2897974793 countsByYear W28979747932023 @default.
• W2897974793 crossrefType "journal-article" @default.
• W2897974793 hasAuthorship W2897974793A5013322398 @default.
• W2897974793 hasAuthorship W2897974793A5020360606 @default.
• W2897974793 hasAuthorship W2897974793A5041161409 @default.
• W2897974793 hasAuthorship W2897974793A5050463530 @default.
• W2897974793 hasAuthorship W2897974793A5057820435 @default.

• next