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- W2897975460 endingPage "25" @default.
- W2897975460 startingPage "14" @default.
- W2897975460 abstract "A phase I trial of an engineered poliovirus for the treatment of recurrent glioblastoma (GBM) has attracted attention due to 8 survivors reaching the 24-month and 5 reaching the 36-month survival landmarks.1 Genetically engineered viruses (oncolytic viruses) have been in trials for GBM for almost two decades.2 These replication-competent (tumor-selective, oncolytic, replication-conditional) viruses or replication-defective viral vectors (gene therapy) deliver cytotoxic payloads to tumors, leading to immunogenic death and intratumoral inflammatory responses. This transforms the tumor microenvironment from immunologically naïve (“cold”) to inflamed (“hot”), increasing immune cell recognition of tumor antigens and the durable responses observed in virotherapy.3,4 Several current and past virotherapy trials have reported a “tail” of apparent responders at the 24-month landmark. Other modalities have also reported a “tail” of seemingly long-term survivors. These trials seem to show that these responder “tails” characterize a defined subset of GBM patients." @default.
- W2897975460 created "2018-10-26" @default.
- W2897975460 creator A5007013927 @default.
- W2897975460 creator A5012381716 @default.
- W2897975460 creator A5033917464 @default.
- W2897975460 creator A5061241022 @default.
- W2897975460 creator A5072584423 @default.
- W2897975460 date "2018-10-22" @default.
- W2897975460 modified "2023-10-16" @default.
- W2897975460 title "Viral and other therapies for recurrent glioblastoma: is a 24-month durable response unusual?" @default.
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