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• W2897976761 abstract "Abstract Background and Aim Although treatment with direct‐acting antivirals has dramatically improved morbidity and mortality attributable to chronic hepatitis C virus infection, universal access to these medicines has been slow in the Asia–Pacific region and Russia. This study evaluated efficacy and safety of elbasvir/grazoprevir in participants with hepatitis C virus infection from Asia–Pacific countries and Russia (C‐CORAL). Methods C‐CORAL was a phase 3, randomized, placebo‐controlled study (NCT02251990). Treatment‐naive, HIV‐negative, cirrhotic and non‐cirrhotic participants with chronic hepatitis C genotype 1, 4, or 6 infection were randomized to elbasvir 50 mg/grazoprevir 100 mg once daily for 12 weeks (immediate‐treatment group) or placebo followed by deferred treatment with elbasvir/grazoprevir (deferred‐treatment group). The primary efficacy outcome was sustained virologic response at 12 weeks, and the primary safety outcome was a comparison between the immediate‐treatment group and placebo phase of the deferred‐treatment group. Results A total of 489 participants were randomized (immediate‐treatment group, n = 366; deferred‐treatment group, n = 123). Sustained virologic response at 12 weeks in the combined immediate/deferred‐treatment groups was 94.4% (459/486; 95% confidence interval = 92.4–96.5%). Sustained virologic response at 12 weeks was 98.2% in participants with genotype 1b, 91.9% with genotype 1a, and 66.7% with genotype 6 infection. Similar rates of adverse events and drug‐related adverse events were seen in the immediate‐treatment group versus placebo phase of the deferred‐treatment group (51.0% vs 50.4% and 21.4% vs 21.1%). Conclusions Elbasvir/grazoprevir for 12 weeks represents an effective and well‐tolerated treatment option for treatment‐naive people with genotype 1 infection from Asia–Pacific countries and Russia." @default.
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• W2897976761 date "2018-12-09" @default.
• W2897976761 modified "2023-10-14" @default.
• W2897976761 title "Efficacy and safety of elbasvir/grazoprevir in participants with hepatitis C virus genotype 1, 4, or 6 infection from the Asia–Pacific region and Russia: Final results from the randomized C‐CORAL study" @default.
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• W2897976761 doi "https://doi.org/10.1111/jgh.14509" @default.
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