Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897979387> ?p ?o ?g. }
- W2897979387 abstract "Integrin β1 is known to be involved in differentiation, migration, proliferation, wound repair, tissue development, and organogenesis. In order to analyze the binding probability between integrin β1 ligand and cluster of differentiation 29 (CD29) receptors, atomic force microscopy (AFM) was used to detect native integrin β1-coupled receptors on the surface of human adipose-derived stem cells (hADSc). The binding probability of integrin β1 ligand–receptor interaction was probed by integrin β1-functionalized tips on hADSc during early chondrogenic differentiation at the two-dimensional cell culture level. Cell morphology and ultrastructure of hADSc were measured by AFM, which demonstrated that long spindled cells became polygonal cells with decreased length/width ratios and increased roughness during chondrogenic induction. The binding of integrin β1 ligand and CD29 receptors was detected by β1-functionalized tips for living hADSc. A total of 1200 curves were recorded at 0, 6, and 12 days of chondrogenic induction. Average rupture forces were, respectively, 61.8 ± 22.2 pN, 60 ± 20.2 pN, and 67.2 ± 22.0 pN. Rupture events were 19.58 ± 1.74%, 28.03 ± 2.05%, and 33.4 ± 1.89%, respectively, which demonstrated that binding probability was increased between integrin β1 ligand and receptors on the surface of hADSc during chondrogenic induction. Integrin β1 and the β-catenin/SOX signaling pathway were correlated during chondrogenic differentiation. The results of this investigation imply that AFM offers kinetic and visual insight into the changes in integrin β1 ligand–CD29 receptor binding on hADSc during chondrogenesis. Changes in cellular morphology, membrane ultrastructure, and the probability of ligand–transmembrane receptor binding were demonstrated to be useful markers for evaluation of the chondrogenic differentiation process." @default.
- W2897979387 created "2018-10-26" @default.
- W2897979387 creator A5001453496 @default.
- W2897979387 creator A5003430134 @default.
- W2897979387 creator A5018810466 @default.
- W2897979387 creator A5020344633 @default.
- W2897979387 creator A5030841696 @default.
- W2897979387 creator A5038074690 @default.
- W2897979387 creator A5053218462 @default.
- W2897979387 creator A5058279520 @default.
- W2897979387 creator A5087748027 @default.
- W2897979387 date "2018-10-23" @default.
- W2897979387 modified "2023-10-16" @default.
- W2897979387 title "Atomic Force Microscopy-Based Nanoscopy of Chondrogenically Differentiating Human Adipose-Derived Stem Cells: Nanostructure and Integrin β1 Expression" @default.
- W2897979387 cites W1522000205 @default.
- W2897979387 cites W1978450685 @default.
- W2897979387 cites W1980769618 @default.
- W2897979387 cites W1999307390 @default.
- W2897979387 cites W2000804108 @default.
- W2897979387 cites W2002214148 @default.
- W2897979387 cites W2014362480 @default.
- W2897979387 cites W2014733626 @default.
- W2897979387 cites W2015050458 @default.
- W2897979387 cites W2029833454 @default.
- W2897979387 cites W2041401385 @default.
- W2897979387 cites W2042409961 @default.
- W2897979387 cites W2049642425 @default.
- W2897979387 cites W2068682888 @default.
- W2897979387 cites W2070565156 @default.
- W2897979387 cites W2079252618 @default.
- W2897979387 cites W2112797083 @default.
- W2897979387 cites W2123714811 @default.
- W2897979387 cites W2131717149 @default.
- W2897979387 cites W2140513563 @default.
- W2897979387 cites W2143076230 @default.
- W2897979387 cites W2144023435 @default.
- W2897979387 cites W2156293127 @default.
- W2897979387 cites W2215498243 @default.
- W2897979387 cites W2287912876 @default.
- W2897979387 cites W2463481177 @default.
- W2897979387 cites W2604286980 @default.
- W2897979387 cites W2605036014 @default.
- W2897979387 cites W2607256816 @default.
- W2897979387 cites W2613221735 @default.
- W2897979387 cites W2772660815 @default.
- W2897979387 cites W2772716333 @default.
- W2897979387 cites W3189920043 @default.
- W2897979387 doi "https://doi.org/10.1186/s11671-018-2722-z" @default.
- W2897979387 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6199198" @default.
- W2897979387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30353236" @default.
- W2897979387 hasPublicationYear "2018" @default.
- W2897979387 type Work @default.
- W2897979387 sameAs 2897979387 @default.
- W2897979387 citedByCount "1" @default.
- W2897979387 countsByYear W28979793872021 @default.
- W2897979387 crossrefType "journal-article" @default.
- W2897979387 hasAuthorship W2897979387A5001453496 @default.
- W2897979387 hasAuthorship W2897979387A5003430134 @default.
- W2897979387 hasAuthorship W2897979387A5018810466 @default.
- W2897979387 hasAuthorship W2897979387A5020344633 @default.
- W2897979387 hasAuthorship W2897979387A5030841696 @default.
- W2897979387 hasAuthorship W2897979387A5038074690 @default.
- W2897979387 hasAuthorship W2897979387A5053218462 @default.
- W2897979387 hasAuthorship W2897979387A5058279520 @default.
- W2897979387 hasAuthorship W2897979387A5087748027 @default.
- W2897979387 hasBestOaLocation W28979793871 @default.
- W2897979387 hasConcept C170493617 @default.
- W2897979387 hasConcept C185592680 @default.
- W2897979387 hasConcept C195687474 @default.
- W2897979387 hasConcept C28328180 @default.
- W2897979387 hasConcept C35496256 @default.
- W2897979387 hasConcept C55493867 @default.
- W2897979387 hasConcept C86803240 @default.
- W2897979387 hasConcept C95444343 @default.
- W2897979387 hasConceptScore W2897979387C170493617 @default.
- W2897979387 hasConceptScore W2897979387C185592680 @default.
- W2897979387 hasConceptScore W2897979387C195687474 @default.
- W2897979387 hasConceptScore W2897979387C28328180 @default.
- W2897979387 hasConceptScore W2897979387C35496256 @default.
- W2897979387 hasConceptScore W2897979387C55493867 @default.
- W2897979387 hasConceptScore W2897979387C86803240 @default.
- W2897979387 hasConceptScore W2897979387C95444343 @default.
- W2897979387 hasFunder F4320321001 @default.
- W2897979387 hasFunder F4320321543 @default.
- W2897979387 hasIssue "1" @default.
- W2897979387 hasLocation W28979793871 @default.
- W2897979387 hasLocation W28979793872 @default.
- W2897979387 hasLocation W28979793873 @default.
- W2897979387 hasLocation W28979793874 @default.
- W2897979387 hasOpenAccess W2897979387 @default.
- W2897979387 hasPrimaryLocation W28979793871 @default.
- W2897979387 hasRelatedWork W1987588903 @default.
- W2897979387 hasRelatedWork W1997969373 @default.
- W2897979387 hasRelatedWork W2026303159 @default.
- W2897979387 hasRelatedWork W2041745288 @default.
- W2897979387 hasRelatedWork W2046022275 @default.
- W2897979387 hasRelatedWork W2146649239 @default.
- W2897979387 hasRelatedWork W2516015895 @default.
- W2897979387 hasRelatedWork W3120507315 @default.
- W2897979387 hasRelatedWork W4376872956 @default.