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• W2897987013 abstract "Comprehensive assessment of general health (physical and mental/cognitive) can increase late life disease prediction. The aim of this research was to understand how NFI could help to predict cognitive changes in elderly people with heart disease. The participants represent individuals drawn from the Canadian Study of Health and Aging (CSHA). The CSHA was conducted in three waves: CSHA-1 (1991 to 1992) and CSHA-2 (1996 to 1997). In this study we just used data from wave 1 and 2 for prediction of 5-year cognitive changes. Samples included those who completed neuropsychological tests at CSHA-1 and received a clinical diagnostic assessment at CSHA-1 and CSHA-2 (n = 1228). The current analysis focused on the 997 participants who received a consensus diagnosis of No cognitive impairment (NCI) or cognitive impairment but not dementia (CIND) on CSHA-1. The CIND category was contained of individuals whose level of cognitive impairment was evaluated to be greater than the NCI group but less than the Dementia group. NFI (Neurocognitive Frailty Index) was defined as a combined score of 42 physical and mental components (in 8 cognitive domains) as they were available in the dataset. Cognitive score (measure by 3MS) at follow-up was outcome. At baseline, the mean age of sample was 80.4 year (SD=6.9; Range of 66-100). The NFI mean was 9.93 (SD=6.15) and ranged from 0 to 33). In the multiple linear regression analysis, adjusted for age, gender and 3MS at baseline, the NFI was correlated to 3MS at follow-up same as age (p<0.05). Every additional deficit used to calculate the NFI was associated with an increased chance of cognitive decline. However this Association was stronger in people with heart disease. NFI was significantly associated with cognitive changes for the people with heart disease and this association was stronger than age (p<0.05)." @default.
• W2897987013 created "2018-10-26" @default.
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• W2897987013 date "2018-07-01" @default.
• W2897987013 modified "2023-10-16" @default.
• W2897987013 title "P2‐490: VALIDATION OF NEUROCOGNITIVE FRAILTY INDEX (NFI) IN PEOPLE WITH HEART DISEASE" @default.
• W2897987013 doi "https://doi.org/10.1016/j.jalz.2018.06.1183" @default.
• W2897987013 hasPublicationYear "2018" @default.
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