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• W2897987871 endingPage "35194" @default.
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• W2897987871 abstract "// Frank Griesinger 1 , Julia Roeper 1 , Christoph Pöttgen 2 , Kay C. Willborn 3 and Wilfried E.E. Eberhardt 4 1 Department of Hematology and Oncology, University Department Internal Medicine-Oncology, Pius-Hospital, Medical Campus University of Oldenburg, Oldenburg, Germany 2 Department of Radiotherapy, University Hospital Essen, Essen, Germany 3 Department of Radiotherapy and Radiooncology, University Department of Medical Physics, Pius-Hospital Oldenburg, University of Oldenburg, Oldenburg, Germany 4 Department of Medical Oncology, West German Cancer Center, Ruhrlandklinik, University of Duisburg-Essen, Essen, Germany Correspondence to: Frank Griesinger, email: Frank.Griesinger@Pius-Hospital.de Keywords: non-small cell lung cancer; ALK-positive; brain metastases; ALK-inhibitors Received: January 18, 2018      Accepted: August 05, 2018      Published: October 12, 2018 ABSTRACT The progress in molecular biology has revolutionized systemic treatment of advanced non-small-cell lung cancer (NSCLC) from conventional chemotherapy to a treatment stratified by histology and genetic aberrations. Tumors harboring a translocation of the anaplastic-lymphoma-kinase (ALK) gene constitute a distinct genetic and clinico-pathologic NSCLC subtype with patients with ALK-positive disease being at a higher risk for developing brain metastases. Due to the introduction of effective targeted therapy with ALK-inhibitors, today, patients with advanced ALK-positive NSCLC achieve high overall response rates and remain progression-free for long time intervals. Moreover, ALK-inhibitors seem to exhibit efficacy in the treatment of brain metastases. In the light of this, it needs to be discussed how treatment algorithms for managing patients with brain metastases should be modified. By integrating systemic ALK-inhibitor therapy, radiotherapy, in particular whole brain radiotherapy might be postponed deferring potential long-term impairment by neurocognitive deficits to a later time point in the course of the disease. An early treatment of asymptomatic brain metastases might offer patients a longer time without impairment of cerebral symptoms or radiotherapeutic interventions. Based on an updated extensive review of the literature this article provides an overview on the epidemiology and the treatment of patients’ brain metastases. It describes the specifics of ALK-positive disease and proposes an algorithm for the treatment of patients with advanced ALK-positive NSCLC and brain metastases." @default.
• W2897987871 created "2018-10-26" @default.
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• W2897987871 date "2018-10-12" @default.
• W2897987871 modified "2023-10-06" @default.
• W2897987871 title "Brain metastases in ALK-positive NSCLC - time to adjust current treatment algorithms" @default.
• W2897987871 cites W1577231758 @default.
• W2897987871 cites W187617824 @default.
• W2897987871 cites W1965615508 @default.
• W2897987871 cites W1966683718 @default.
• W2897987871 cites W1974820090 @default.
• W2897987871 cites W1978401308 @default.
• W2897987871 cites W1988635422 @default.
• W2897987871 cites W1990626198 @default.
• W2897987871 cites W2004046560 @default.
• W2897987871 cites W2010561682 @default.
• W2897987871 cites W2010619956 @default.
• W2897987871 cites W2015436643 @default.
• W2897987871 cites W2016112560 @default.
• W2897987871 cites W2022689141 @default.
• W2897987871 cites W2025489612 @default.
• W2897987871 cites W2029218729 @default.
• W2897987871 cites W2031159738 @default.
• W2897987871 cites W2031494655 @default.
• W2897987871 cites W2036611968 @default.
• W2897987871 cites W2037503358 @default.
• W2897987871 cites W2040636001 @default.
• W2897987871 cites W2041752578 @default.
• W2897987871 cites W2041835001 @default.
• W2897987871 cites W2042623581 @default.
• W2897987871 cites W2049465373 @default.
• W2897987871 cites W2050249255 @default.
• W2897987871 cites W2055402151 @default.
• W2897987871 cites W2069501893 @default.
• W2897987871 cites W2079474602 @default.
• W2897987871 cites W2082065697 @default.
• W2897987871 cites W2090323980 @default.
• W2897987871 cites W2091639070 @default.
• W2897987871 cites W2096156234 @default.
• W2897987871 cites W2099530756 @default.
• W2897987871 cites W2100379216 @default.
• W2897987871 cites W2104165122 @default.
• W2897987871 cites W2104830962 @default.
• W2897987871 cites W2107869150 @default.
• W2897987871 cites W2109950864 @default.
• W2897987871 cites W2112117200 @default.
• W2897987871 cites W2116478428 @default.
• W2897987871 cites W2121005606 @default.
• W2897987871 cites W2123727052 @default.
• W2897987871 cites W2123753884 @default.
• W2897987871 cites W2126660668 @default.
• W2897987871 cites W2127596453 @default.
• W2897987871 cites W2128871519 @default.
• W2897987871 cites W2128925190 @default.
• W2897987871 cites W2130488043 @default.
• W2897987871 cites W2135121296 @default.
• W2897987871 cites W2139110945 @default.
• W2897987871 cites W2141604895 @default.
• W2897987871 cites W2143843774 @default.
• W2897987871 cites W2151116840 @default.
• W2897987871 cites W2158010175 @default.
• W2897987871 cites W2163351155 @default.
• W2897987871 cites W2166692084 @default.
• W2897987871 cites W2168106545 @default.
• W2897987871 cites W2168691181 @default.
• W2897987871 cites W2170736348 @default.
• W2897987871 cites W2174368583 @default.
• W2897987871 cites W2208535430 @default.
• W2897987871 cites W2212917847 @default.
• W2897987871 cites W2221837786 @default.
• W2897987871 cites W2239178472 @default.
• W2897987871 cites W2239287815 @default.
• W2897987871 cites W2265851150 @default.
• W2897987871 cites W2280957887 @default.
• W2897987871 cites W2295354328 @default.
• W2897987871 cites W2324520777 @default.
• W2897987871 cites W2464088142 @default.
• W2897987871 cites W2475230058 @default.
• W2897987871 cites W2492871464 @default.
• W2897987871 cites W2494947788 @default.
• W2897987871 cites W2581996620 @default.
• W2897987871 cites W2586673947 @default.
• W2897987871 cites W2587099123 @default.
• W2897987871 cites W2589099669 @default.
• W2897987871 cites W2589202867 @default.
• W2897987871 cites W2595412422 @default.
• W2897987871 cites W2610816290 @default.
• W2897987871 cites W2613260339 @default.
• W2897987871 cites W2614270084 @default.
• W2897987871 cites W2623725180 @default.
• W2897987871 cites W2624310346 @default.
• W2897987871 cites W2737387235 @default.
• W2897987871 cites W2761982099 @default.
• W2897987871 cites W2796631032 @default.

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