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• W2897988811 endingPage "061001" @default.
• W2897988811 startingPage "061001" @default.
• W2897988811 abstract "Implantable electronics address therapeutical needs of patients with electrical signaling dysfunctions such as heart problems, neurological disorders or hearing impairments. While standard electronics are rigid, planar and made of hard materials, their surrounding biological tissues are soft, wet and constantly in motion. These intrinsic differences in mechanical and chemical properties cause physiological responses that constitute a fundamental challenge to create functional long-term interfaces. Using soft and stretchable materials for electronic implants decreases the mechanical mismatch between implant and biological tissues. As a result, tissue damage during and after implantation is reduced, leading not only to an attenuated foreign body response, but also enabling completely novel applications. However, but for a few exceptions, soft materials are not sufficient to create long-term stable functional implants. In this work, we review recent progress in interfacing both the central (CNS) and peripheral nervous system (PNS) for long-term functional devices. The basics of soft and stretchable devices are introduced by highlighting the importance of minimizing physical as well as mechanical mismatch between tissue and implant in the CNS and emphasizing the relevance of an appropriate surface chemistry for implants in the PNS. Finally, we report on the latest materials and techniques that provide further electronic enhancements while reducing the foreign body reaction. Thus, this review should serve as a guide for creating long-term functional implants to enable future healthcare technologies and as a discussion on current ideas and progress within the field." @default.
• W2897988811 created "2018-10-26" @default.
• W2897988811 creator A5014412286 @default.
• W2897988811 creator A5032407760 @default.
• W2897988811 creator A5035701091 @default.
• W2897988811 creator A5049498000 @default.
• W2897988811 creator A5051062804 @default.
• W2897988811 date "2018-10-16" @default.
• W2897988811 modified "2023-09-25" @default.
• W2897988811 title "A guide towards long-term functional electrodes interfacing neuronal tissue" @default.
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