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- W2898001491 abstract "Cataracts are responsible for half of the world blindness, surgery being the only viable treatment. Lutein, a naturally occurring carotenoid in the eye, has the potential to reduce cataract progression by protecting the eye from photo-oxidative stress. To restore the eye's natural line of defense against photo-oxidative stress, a formulation was developed using zein and poly(lactic-co-glycolic acid) nanoparticles (NPs) embedded in an optimized bioadhesive thermosensitive gel for the delivery of lutein via topical application. Cataracts were induced in Crl:WI rats via selenite injection at 13 days post-partum, followed by 7 days of treatment with free lutein or lutein-loaded NPs administered orally or topically. Cataract severity was significantly reduced in rats treated with topical applications of lutein-loaded NPs compared to the positive control, while no significant differences were observed in rats treated with other lutein formulations including oral and topically applied free lutein." @default.
- W2898001491 created "2018-10-26" @default.
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- W2898001491 date "2019-01-01" @default.
- W2898001491 modified "2023-10-17" @default.
- W2898001491 title "Topical nanodelivery system of lutein for the prevention of selenite-induced cataract" @default.
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- W2898001491 doi "https://doi.org/10.1016/j.nano.2018.09.016" @default.
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