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• W2898018045 abstract "Plasma biomarkers that identify abdominal aortic aneurysm (AAA) rupture risk would greatly assist in stratifying patients with small aneurysms. Identification of such biomarkers has hitherto been unsuccessful over a range of studies using different methods. The present study used an alternative proteomic approach to find new, potential plasma AAA biomarker candidates. Pre-fractionated plasma samples from twelve patients with AAA and eight matched controls without aneurysm were analyzed by mass spectrometry applying a tandem mass tag (TMT) technique. Eight proteins were differentially regulated in patients compared to controls, including decreased levels of the enzyme bleomycin hydrolase. The down-regulation of this enzyme was confirmed in an extended validation study using an enzyme-linked immunosorbent assay (ELISA). The TMT-based proteomic approach thus identified novel potential plasma biomarkers for AAA." @default.
• W2898018045 created "2018-10-26" @default.
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• W2898018045 date "2018-10-18" @default.
• W2898018045 modified "2023-09-26" @default.
• W2898018045 title "Identification of Potential Plasma Biomarkers for Abdominal Aortic Aneurysm Using Tandem Mass Tag Quantitative Proteomics" @default.
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• W2898018045 doi "https://doi.org/10.3390/proteomes6040043" @default.
• W2898018045 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6313917" @default.
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