FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898020577> ?p ?o ?g. }

• W2898020577 abstract "Developmental physiology is very sensitive to nutrient availability. For instance, in the nematode Caenorhabditis elegans, newly hatched L1-stage larvae require food to initiate postembryonic development. In addition, larvae arrested in the dauer diapause, a non-feeding state of developmental arrest that occurs during the L3 stage, initiate recovery when exposed to food. Despite the essential role of food in C. elegans development, the contribution of food perception versus ingestion on physiology has not been delineated. We used a pharmacological approach to uncouple the effects of food (bacteria) perception and ingestion in C. elegans. Perception was not sufficient to promote postembryonic development in L1-stage larvae. However, L1 larvae exposed to food without ingestion failed to develop upon return to normal culture conditions, instead displaying an irreversible arrest phenotype. Inhibition of gene expression during perception rescued subsequent development, demonstrating that the response to perception without feeding is deleterious. Perception altered DAF-16/FOXO subcellular localization, reflecting activation of insulin/IGF signaling (IIS). The insulin-like peptide daf-28 was specifically required, suggesting perception in chemosensory neurons, where it is expressed, regulates peptide synthesis and possibly secretion. However, genetic manipulation of IIS did not modify the irreversible arrest phenotype caused by food perception, revealing that wild-type function of the IIS pathway is not required to produce this phenotype and that other pathways affected by perception of food in the absence of its ingestion are likely to be involved. Gene expression and Nile red staining showed that food perception could alter lipid metabolism and storage. We found that starved larvae sense environmental polypeptides, with similar molecular and developmental effects as perception of bacteria. Environmental polypeptides also promoted recovery from dauer diapause, suggesting that perception of polypeptides plays an important role in the life history of free-living nematodes. We conclude that actual ingestion of food is required to initiate postembryonic development in C. elegans. We also conclude that polypeptides are perceived as a food-associated cue in this and likely other animals, initiating a signaling and gene regulatory cascade that alters metabolism in anticipation of feeding and development, but that this response is detrimental if feeding does not occur." @default.
• W2898020577 created "2018-10-26" @default.
• W2898020577 creator A5010645292 @default.
• W2898020577 creator A5027310847 @default.
• W2898020577 creator A5036492412 @default.
• W2898020577 creator A5058457816 @default.
• W2898020577 creator A5064847175 @default.
• W2898020577 date "2018-10-08" @default.
• W2898020577 modified "2023-10-01" @default.
• W2898020577 title "Food perception without ingestion leads to metabolic changes and irreversible developmental arrest in C. elegans" @default.
• W2898020577 cites W1510306828 @default.
• W2898020577 cites W1587592813 @default.
• W2898020577 cites W1631908837 @default.
• W2898020577 cites W1797898354 @default.
• W2898020577 cites W1907390239 @default.
• W2898020577 cites W1965404074 @default.
• W2898020577 cites W1966145280 @default.
• W2898020577 cites W1967170498 @default.
• W2898020577 cites W1971374859 @default.
• W2898020577 cites W1971446667 @default.
• W2898020577 cites W1976054510 @default.
• W2898020577 cites W1981093360 @default.
• W2898020577 cites W1982073015 @default.
• W2898020577 cites W1986006829 @default.
• W2898020577 cites W1990185604 @default.
• W2898020577 cites W1991080848 @default.
• W2898020577 cites W1992326265 @default.
• W2898020577 cites W2008616131 @default.
• W2898020577 cites W2011364906 @default.
• W2898020577 cites W2016075650 @default.
• W2898020577 cites W2021874236 @default.
• W2898020577 cites W2029905838 @default.
• W2898020577 cites W2032285280 @default.
• W2898020577 cites W2038963685 @default.
• W2898020577 cites W2047495081 @default.
• W2898020577 cites W2049220511 @default.
• W2898020577 cites W2049977474 @default.
• W2898020577 cites W2055920458 @default.
• W2898020577 cites W2056777384 @default.
• W2898020577 cites W2057264061 @default.
• W2898020577 cites W2057575035 @default.
• W2898020577 cites W2057882511 @default.
• W2898020577 cites W2061428578 @default.
• W2898020577 cites W2062629127 @default.
• W2898020577 cites W2067517788 @default.
• W2898020577 cites W2069237005 @default.
• W2898020577 cites W2080802801 @default.
• W2898020577 cites W2081267709 @default.
• W2898020577 cites W2083850113 @default.
• W2898020577 cites W2091617571 @default.
• W2898020577 cites W2094231976 @default.
• W2898020577 cites W2103017472 @default.
• W2898020577 cites W2103846905 @default.
• W2898020577 cites W2105326400 @default.
• W2898020577 cites W2108024591 @default.
• W2898020577 cites W2114104545 @default.
• W2898020577 cites W2114713612 @default.
• W2898020577 cites W2120227399 @default.
• W2898020577 cites W2124985265 @default.
• W2898020577 cites W2133318178 @default.
• W2898020577 cites W2134526812 @default.
• W2898020577 cites W2134975446 @default.
• W2898020577 cites W2141478455 @default.
• W2898020577 cites W2141545183 @default.
• W2898020577 cites W2148521682 @default.
• W2898020577 cites W2152061056 @default.
• W2898020577 cites W2152177859 @default.
• W2898020577 cites W2166222890 @default.
• W2898020577 cites W2195939363 @default.
• W2898020577 cites W2557989248 @default.
• W2898020577 cites W2604808360 @default.
• W2898020577 cites W2725084213 @default.
• W2898020577 cites W2765389667 @default.
• W2898020577 cites W4238773213 @default.
• W2898020577 cites W4241181595 @default.
• W2898020577 doi "https://doi.org/10.1186/s12915-018-0579-3" @default.
• W2898020577 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6176503" @default.
• W2898020577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30296941" @default.
• W2898020577 hasPublicationYear "2018" @default.
• W2898020577 type Work @default.
• W2898020577 sameAs 2898020577 @default.
• W2898020577 citedByCount "14" @default.
• W2898020577 countsByYear W28980205772020 @default.
• W2898020577 countsByYear W28980205772021 @default.
• W2898020577 countsByYear W28980205772022 @default.
• W2898020577 countsByYear W28980205772023 @default.
• W2898020577 crossrefType "journal-article" @default.
• W2898020577 hasAuthorship W2898020577A5010645292 @default.
• W2898020577 hasAuthorship W2898020577A5027310847 @default.
• W2898020577 hasAuthorship W2898020577A5036492412 @default.
• W2898020577 hasAuthorship W2898020577A5058457816 @default.
• W2898020577 hasAuthorship W2898020577A5064847175 @default.
• W2898020577 hasBestOaLocation W28980205771 @default.
• W2898020577 hasConcept C104317684 @default.
• W2898020577 hasConcept C127716648 @default.
• W2898020577 hasConcept C173758957 @default.
• W2898020577 hasConcept C18903297 @default.
• W2898020577 hasConcept C193230392 @default.
• W2898020577 hasConcept C2778944004 @default.
• W2898020577 hasConcept C54355233 @default.

• next