Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898021127> ?p ?o ?g. }
- W2898021127 endingPage "11758" @default.
- W2898021127 startingPage "11743" @default.
- W2898021127 abstract "Eyeless (ey) is one of the most critical transcription factors for initiating the entire eye development in Drosophila. However, the molecular mechanisms through which Ey regulates target genes and pathways have not been characterized at the genomic level. Using ChIP-Seq, we generated an endogenous Ey-binding profile in Drosophila developing eyes. We found that Ey binding occurred more frequently at promoter compared to non-promoter regions. Ey promoter binding was correlated with the active transcription of genes involved in development and transcription regulation. An integrative analysis revealed that Ey directly regulated a broad and highly connected genetic network, including many essential patterning pathways, and known and novel eye genes. Interestingly, we observed that Ey could target multiple components of the same pathway, which might enhance its control of these pathways during eye development. In addition to protein-coding genes, we discovered Ey also targeted non-coding RNAs, which represents a new regulatory mechanism employed by Ey. These findings suggest that Ey could use multiple molecular mechanisms to regulate target gene expression and pathway function, which might enable Ey to exhibit a greater flexibility in controlling different processes during eye development." @default.
- W2898021127 created "2018-10-26" @default.
- W2898021127 creator A5002521571 @default.
- W2898021127 creator A5007472107 @default.
- W2898021127 creator A5012493628 @default.
- W2898021127 creator A5053453125 @default.
- W2898021127 creator A5056774825 @default.
- W2898021127 creator A5088671312 @default.
- W2898021127 date "2018-10-08" @default.
- W2898021127 modified "2023-10-03" @default.
- W2898021127 title "Integrative genomic analysis reveals novel regulatory mechanisms of<i>eyeless</i>during<i>Drosophila</i>eye development" @default.
- W2898021127 cites W1485160270 @default.
- W2898021127 cites W1581074054 @default.
- W2898021127 cites W1608783464 @default.
- W2898021127 cites W1661341289 @default.
- W2898021127 cites W1845299304 @default.
- W2898021127 cites W1846630060 @default.
- W2898021127 cites W1910994615 @default.
- W2898021127 cites W1964761197 @default.
- W2898021127 cites W1974595249 @default.
- W2898021127 cites W1974714162 @default.
- W2898021127 cites W1979400866 @default.
- W2898021127 cites W1979509014 @default.
- W2898021127 cites W1981030303 @default.
- W2898021127 cites W1985840612 @default.
- W2898021127 cites W1986382645 @default.
- W2898021127 cites W1997339096 @default.
- W2898021127 cites W2007054766 @default.
- W2898021127 cites W2007684630 @default.
- W2898021127 cites W2011408477 @default.
- W2898021127 cites W2014094760 @default.
- W2898021127 cites W2019005509 @default.
- W2898021127 cites W2022620053 @default.
- W2898021127 cites W2024490391 @default.
- W2898021127 cites W2036993884 @default.
- W2898021127 cites W2039728576 @default.
- W2898021127 cites W2042048739 @default.
- W2898021127 cites W2046128077 @default.
- W2898021127 cites W2049361027 @default.
- W2898021127 cites W2050566666 @default.
- W2898021127 cites W2054937560 @default.
- W2898021127 cites W2063728571 @default.
- W2898021127 cites W2066576345 @default.
- W2898021127 cites W2068205741 @default.
- W2898021127 cites W2070738655 @default.
- W2898021127 cites W2071575397 @default.
- W2898021127 cites W2077905736 @default.
- W2898021127 cites W2084191969 @default.
- W2898021127 cites W2090268833 @default.
- W2898021127 cites W2092252450 @default.
- W2898021127 cites W2098466396 @default.
- W2898021127 cites W2099805939 @default.
- W2898021127 cites W2102589238 @default.
- W2898021127 cites W2102619694 @default.
- W2898021127 cites W2103374655 @default.
- W2898021127 cites W2103441770 @default.
- W2898021127 cites W2103654030 @default.
- W2898021127 cites W2109433965 @default.
- W2898021127 cites W2115358825 @default.
- W2898021127 cites W2119594523 @default.
- W2898021127 cites W2120213194 @default.
- W2898021127 cites W2123564569 @default.
- W2898021127 cites W2128479193 @default.
- W2898021127 cites W2135131807 @default.
- W2898021127 cites W2139125991 @default.
- W2898021127 cites W2140952049 @default.
- W2898021127 cites W2145995659 @default.
- W2898021127 cites W2151011371 @default.
- W2898021127 cites W2152032402 @default.
- W2898021127 cites W2154040587 @default.
- W2898021127 cites W2157009395 @default.
- W2898021127 cites W2158217645 @default.
- W2898021127 cites W2158642237 @default.
- W2898021127 cites W2163573865 @default.
- W2898021127 cites W2165089629 @default.
- W2898021127 cites W2167249461 @default.
- W2898021127 cites W2168602111 @default.
- W2898021127 cites W2169537162 @default.
- W2898021127 cites W2169988786 @default.
- W2898021127 cites W2171808845 @default.
- W2898021127 cites W2172162107 @default.
- W2898021127 cites W2187079233 @default.
- W2898021127 cites W2432769034 @default.
- W2898021127 cites W947309 @default.
- W2898021127 doi "https://doi.org/10.1093/nar/gky892" @default.
- W2898021127 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6294497" @default.
- W2898021127 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30295802" @default.
- W2898021127 hasPublicationYear "2018" @default.
- W2898021127 type Work @default.
- W2898021127 sameAs 2898021127 @default.
- W2898021127 citedByCount "8" @default.
- W2898021127 countsByYear W28980211272020 @default.
- W2898021127 countsByYear W28980211272021 @default.
- W2898021127 countsByYear W28980211272022 @default.
- W2898021127 crossrefType "journal-article" @default.
- W2898021127 hasAuthorship W2898021127A5002521571 @default.
- W2898021127 hasAuthorship W2898021127A5007472107 @default.
- W2898021127 hasAuthorship W2898021127A5012493628 @default.