FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898021345> ?p ?o ?g. }

• W2898021345 endingPage "9" @default.
• W2898021345 startingPage "1" @default.
• W2898021345 abstract "A rapid and selective UPLC-DAD method was developed and validated for simultaneous analysis of the novel two-drug combination Darvoni ® for the treatment of HCV: Sofosbuvir (SF)/Daclatasvir (DC) in human plasma using Ledipasvir as internal standard (IS) where the extraction process was conducted using automated SPE. Although the analysis of the combination after concomitant oral intake of two tablets of SF and DC individually was reported in literature, yet simultaneous analysis of this new combination in human plasma after a single oral dose was not previously reported. The adopted chromatographic separation was achieved on Waters® Acquity UPLC BEH C 18 column (2.1 × 50 mm, 1.7 µ m) as a stationary phase using isocratic elution using a mobile phase system of ammonium formate (pH 3.5; 5 mM) and acetonitrile (60:40 v/v) pumped at a flow rate of 0.2 mL.min −1 . The UV detection was carried out at 261 nm for SF and 318 nm for DC and IS. SF was eluted at 1.123 min while DC was eluted at 3.179 min. The proposed chromatographic method was validated in accordance with guidelines of FDA for bioanalytical method validation. A linear range was achieved in the range of 25-6400 and 50-12800 ng.mL −1 for SF and DC, respectively. The proposed UPLC-DAD method was found to be accurate with % bias ranging between -10.0-7.2 for SF and -6.9-8.0 for DC. Also it was proved to be precise with % CV for intraday precision ranging between 3.8-9.6 for SF and 2.8-9.2 for DC whereas interday precision ranged between 5.1-9.3 for SF and 3.7-9.1 for DC. Moreover, % extraction recovery ranged between 90.0-107.2 for SF and 93.1-108.0 for DC using the suggested method. The adopted chromatographic method was successfully applied to the therapeutic drug monitoring of SF and DC in healthy volunteers after the oral intake of one Darvoni® tablet." @default.
• W2898021345 created "2018-10-26" @default.
• W2898021345 creator A5014904982 @default.
• W2898021345 creator A5033687024 @default.
• W2898021345 creator A5040136567 @default.
• W2898021345 date "2018-10-21" @default.
• W2898021345 modified "2023-09-30" @default.
• W2898021345 title "Development of a Robust UPLC Method for Simultaneous Determination of a Novel Combination of Sofosbuvir and Daclatasvir in Human Plasma:<i> Clinical Application to Therapeutic Drug Monitoring</i>" @default.
• W2898021345 cites W1955422856 @default.
• W2898021345 cites W1995591620 @default.
• W2898021345 cites W2051589687 @default.
• W2898021345 cites W2068062063 @default.
• W2898021345 cites W2073470509 @default.
• W2898021345 cites W2113615736 @default.
• W2898021345 cites W2113864802 @default.
• W2898021345 cites W2130525876 @default.
• W2898021345 cites W2153237405 @default.
• W2898021345 cites W2254030754 @default.
• W2898021345 cites W2273931191 @default.
• W2898021345 cites W2306227468 @default.
• W2898021345 cites W2325520215 @default.
• W2898021345 cites W2340843616 @default.
• W2898021345 cites W2391942312 @default.
• W2898021345 cites W242691955 @default.
• W2898021345 cites W2528664910 @default.
• W2898021345 cites W2556164327 @default.
• W2898021345 cites W2594883467 @default.
• W2898021345 cites W2753313618 @default.
• W2898021345 cites W2756980400 @default.
• W2898021345 cites W2774508356 @default.
• W2898021345 cites W2782023682 @default.
• W2898021345 cites W2794127837 @default.
• W2898021345 cites W2796084652 @default.
• W2898021345 cites W3145771866 @default.
• W2898021345 doi "https://doi.org/10.1155/2018/6535816" @default.
• W2898021345 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6215565" @default.
• W2898021345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30420886" @default.
• W2898021345 hasPublicationYear "2018" @default.
• W2898021345 type Work @default.
• W2898021345 sameAs 2898021345 @default.
• W2898021345 citedByCount "11" @default.
• W2898021345 countsByYear W28980213452019 @default.
• W2898021345 countsByYear W28980213452020 @default.
• W2898021345 countsByYear W28980213452021 @default.
• W2898021345 countsByYear W28980213452022 @default.
• W2898021345 countsByYear W28980213452023 @default.
• W2898021345 crossrefType "journal-article" @default.
• W2898021345 hasAuthorship W2898021345A5014904982 @default.
• W2898021345 hasAuthorship W2898021345A5033687024 @default.
• W2898021345 hasAuthorship W2898021345A5040136567 @default.
• W2898021345 hasBestOaLocation W28980213451 @default.
• W2898021345 hasConcept C104317684 @default.
• W2898021345 hasConcept C135763542 @default.
• W2898021345 hasConcept C137535248 @default.
• W2898021345 hasConcept C179998833 @default.
• W2898021345 hasConcept C185592680 @default.
• W2898021345 hasConcept C2775986502 @default.
• W2898021345 hasConcept C2775999097 @default.
• W2898021345 hasConcept C2776979040 @default.
• W2898021345 hasConcept C2778390639 @default.
• W2898021345 hasConcept C2780035454 @default.
• W2898021345 hasConcept C2780040827 @default.
• W2898021345 hasConcept C2780272996 @default.
• W2898021345 hasConcept C43617362 @default.
• W2898021345 hasConcept C4725764 @default.
• W2898021345 hasConcept C55493867 @default.
• W2898021345 hasConcept C71924100 @default.
• W2898021345 hasConcept C73826308 @default.
• W2898021345 hasConcept C98274493 @default.
• W2898021345 hasConceptScore W2898021345C104317684 @default.
• W2898021345 hasConceptScore W2898021345C135763542 @default.
• W2898021345 hasConceptScore W2898021345C137535248 @default.
• W2898021345 hasConceptScore W2898021345C179998833 @default.
• W2898021345 hasConceptScore W2898021345C185592680 @default.
• W2898021345 hasConceptScore W2898021345C2775986502 @default.
• W2898021345 hasConceptScore W2898021345C2775999097 @default.
• W2898021345 hasConceptScore W2898021345C2776979040 @default.
• W2898021345 hasConceptScore W2898021345C2778390639 @default.
• W2898021345 hasConceptScore W2898021345C2780035454 @default.
• W2898021345 hasConceptScore W2898021345C2780040827 @default.
• W2898021345 hasConceptScore W2898021345C2780272996 @default.
• W2898021345 hasConceptScore W2898021345C43617362 @default.
• W2898021345 hasConceptScore W2898021345C4725764 @default.
• W2898021345 hasConceptScore W2898021345C55493867 @default.
• W2898021345 hasConceptScore W2898021345C71924100 @default.
• W2898021345 hasConceptScore W2898021345C73826308 @default.
• W2898021345 hasConceptScore W2898021345C98274493 @default.
• W2898021345 hasLocation W28980213451 @default.
• W2898021345 hasLocation W28980213452 @default.
• W2898021345 hasLocation W28980213453 @default.
• W2898021345 hasLocation W28980213454 @default.
• W2898021345 hasLocation W28980213455 @default.
• W2898021345 hasOpenAccess W2898021345 @default.
• W2898021345 hasPrimaryLocation W28980213451 @default.
• W2898021345 hasRelatedWork W1990772217 @default.
• W2898021345 hasRelatedWork W2413352596 @default.
• W2898021345 hasRelatedWork W2522881653 @default.
• W2898021345 hasRelatedWork W2600267429 @default.

• next