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• W2898023150 endingPage "e1007341" @default.
• W2898023150 startingPage "e1007341" @default.
• W2898023150 abstract "Vibrio cholerae and a subset of other Gram-negative bacteria, including Acinetobacter baumannii, express proteins with a C-terminal tripartite domain called GlyGly-CTERM, which consists of a motif rich in glycines and serines, followed by a hydrophobic region and positively charged residues. Here we show that VesB, a V. cholerae serine protease, requires the GlyGly-CTERM domain, the intramembrane rhomboid-like protease rhombosortase, and the type II secretion system (T2SS) for localization at the cell surface. VesB is cleaved by rhombosortase to expose the second glycine residue of the GlyGly-CTERM motif, which is then conjugated to a glycerophosphoethanolamine-containing moiety prior to engagement with the T2SS and outer membrane translocation. In support of this, VesB accumulates intracellularly in the absence of the T2SS, and surface-associated VesB activity is no longer detected when the rhombosortase gene is inactivated. In turn, when VesB is expressed without an intact GlyGly-CTERM domain, VesB is released to the extracellular milieu by the T2SS and does not accumulate on the cell surface. Collectively, our findings suggest that the posttranslational modification of the GlyGly-CTERM domain is essential for cell surface localization of VesB and other proteins expressed with this tripartite extension." @default.
• W2898023150 created "2018-10-26" @default.
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• W2898023150 date "2018-10-23" @default.
• W2898023150 modified "2023-10-17" @default.
• W2898023150 title "C-terminal processing of GlyGly-CTERM containing proteins by rhombosortase in Vibrio cholerae" @default.
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• W2898023150 doi "https://doi.org/10.1371/journal.ppat.1007341" @default.
• W2898023150 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6219818" @default.
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