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• W2898024870 abstract "The production of commercially valuable biotherapeutic molecules in mammalian systems has expanded significantly in the last thirty years, but growing economic pressures within the industry are driving efforts to reduce costs and enhance process yields. At the upstream stage, two complementary approaches have evolved to increase productivity and maintain consistent product quality, that is either by altering the cell directly or by manipulating its environment. This review focuses on novel approaches to impact productivity and product quality by manipulating the environment through: (a) altering media composition; (b) modulating operating conditions such as pH and temperature; or (c) intensifying process operations by switching from fed-batch to continuous processes." @default.
• W2898024870 created "2018-10-26" @default.
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• W2898024870 date "2018-12-01" @default.
• W2898024870 modified "2023-09-29" @default.
• W2898024870 title "Strategies to enhance productivity and modify product quality in therapeutic proteins" @default.
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• W2898024870 doi "https://doi.org/10.1016/j.coche.2018.09.005" @default.
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