FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898032844> ?p ?o ?g. }

• W2898032844 endingPage "10" @default.
• W2898032844 startingPage "1" @default.
• W2898032844 abstract "The objective of this study was to assess the mechanisms underlying pancreatic islet adaptation in diabetic mothers and their pups. Additionally, the influence of pancreatic adaptations on maternal reproductive performance was also investigated. Wistar rats were injected with streptozotocin for diabetes induction. At adulthood (3 months), all animals underwent an oral glucose tolerance test (OGTT) for glucose assessment as an inclusion criterion. Following, the animals were mated. At day 18 of pregnancy, the mothers were killed for blood collect ion to determine fasting insulin and glucagon concentrations. The pancreas was removed and processed for the immunohistochemical analysis of insulin, glucagon, somatostatin, Ki-67 and PDX-1, superoxide dismutase 1 (SOD-1), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA). The pregnant uterus was also collected for the evaluation of embryofetal loss. The diabetic rats showed increased glucose, serum glucagon and insulin concentrations, and embryofetal loss rates. They also showed a reduction in pancreatic islets area and percentage of cells stained for insulin, increased the percentage of non-β cells (alpha e delta cells) stained for Ki-67, glucagon, and somatostatin. Moreover, the cells stained for somatostatin were spread across the islets and showed stronger staining for MDA and weaker staining for GSH-Px. Diabetes leads to adaptive responses from the endocrine pancreas in pregnancy that especially involves non-β cells, modifying the mantle-core structure. Nonetheless, these adaptations are not enough for glucose homeostasis and affect the maternal environment, which in turn impairs fetal development." @default.
• W2898032844 created "2018-10-26" @default.
• W2898032844 creator A5000324926 @default.
• W2898032844 creator A5010655403 @default.
• W2898032844 creator A5018907543 @default.
• W2898032844 creator A5024334020 @default.
• W2898032844 creator A5031604034 @default.
• W2898032844 creator A5036334697 @default.
• W2898032844 creator A5065932486 @default.
• W2898032844 creator A5073189241 @default.
• W2898032844 creator A5087866998 @default.
• W2898032844 date "2018-12-01" @default.
• W2898032844 modified "2023-10-12" @default.
• W2898032844 title "Pancreatic islet response to diabetes during pregnancy in rats" @default.
• W2898032844 cites W1983498402 @default.
• W2898032844 cites W1993046413 @default.
• W2898032844 cites W1998249838 @default.
• W2898032844 cites W2005688198 @default.
• W2898032844 cites W2006722973 @default.
• W2898032844 cites W2007395362 @default.
• W2898032844 cites W2010290591 @default.
• W2898032844 cites W2012238045 @default.
• W2898032844 cites W2014137253 @default.
• W2898032844 cites W2014182850 @default.
• W2898032844 cites W2014299553 @default.
• W2898032844 cites W2023654427 @default.
• W2898032844 cites W2028690161 @default.
• W2898032844 cites W2035940741 @default.
• W2898032844 cites W2037688771 @default.
• W2898032844 cites W2050287666 @default.
• W2898032844 cites W2051491951 @default.
• W2898032844 cites W2061574308 @default.
• W2898032844 cites W2067010864 @default.
• W2898032844 cites W2082515526 @default.
• W2898032844 cites W2082734353 @default.
• W2898032844 cites W2090938409 @default.
• W2898032844 cites W2091101612 @default.
• W2898032844 cites W2094558613 @default.
• W2898032844 cites W2100712899 @default.
• W2898032844 cites W2103612583 @default.
• W2898032844 cites W2105142263 @default.
• W2898032844 cites W2105407346 @default.
• W2898032844 cites W2105518878 @default.
• W2898032844 cites W2110787746 @default.
• W2898032844 cites W2116624274 @default.
• W2898032844 cites W2122327538 @default.
• W2898032844 cites W2123704130 @default.
• W2898032844 cites W2127238864 @default.
• W2898032844 cites W2143485814 @default.
• W2898032844 cites W2145833822 @default.
• W2898032844 cites W2154784486 @default.
• W2898032844 cites W2159859567 @default.
• W2898032844 cites W2165110544 @default.
• W2898032844 cites W2193860999 @default.
• W2898032844 cites W2317544840 @default.
• W2898032844 cites W2405977822 @default.
• W2898032844 cites W2416003593 @default.
• W2898032844 cites W2520636841 @default.
• W2898032844 cites W2538886319 @default.
• W2898032844 cites W2774305703 @default.
• W2898032844 cites W4254965081 @default.
• W2898032844 doi "https://doi.org/10.1016/j.lfs.2018.10.046" @default.
• W2898032844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30366036" @default.
• W2898032844 hasPublicationYear "2018" @default.
• W2898032844 type Work @default.
• W2898032844 sameAs 2898032844 @default.
• W2898032844 citedByCount "20" @default.
• W2898032844 countsByYear W28980328442019 @default.
• W2898032844 countsByYear W28980328442020 @default.
• W2898032844 countsByYear W28980328442021 @default.
• W2898032844 countsByYear W28980328442022 @default.
• W2898032844 countsByYear W28980328442023 @default.
• W2898032844 crossrefType "journal-article" @default.
• W2898032844 hasAuthorship W2898032844A5000324926 @default.
• W2898032844 hasAuthorship W2898032844A5010655403 @default.
• W2898032844 hasAuthorship W2898032844A5018907543 @default.
• W2898032844 hasAuthorship W2898032844A5024334020 @default.
• W2898032844 hasAuthorship W2898032844A5031604034 @default.
• W2898032844 hasAuthorship W2898032844A5036334697 @default.
• W2898032844 hasAuthorship W2898032844A5065932486 @default.
• W2898032844 hasAuthorship W2898032844A5073189241 @default.
• W2898032844 hasAuthorship W2898032844A5087866998 @default.
• W2898032844 hasBestOaLocation W28980328441 @default.
• W2898032844 hasConcept C126322002 @default.
• W2898032844 hasConcept C134018914 @default.
• W2898032844 hasConcept C152091265 @default.
• W2898032844 hasConcept C165220095 @default.
• W2898032844 hasConcept C2776297358 @default.
• W2898032844 hasConcept C2777391703 @default.
• W2898032844 hasConcept C2778563252 @default.
• W2898032844 hasConcept C2778764654 @default.
• W2898032844 hasConcept C2779306644 @default.
• W2898032844 hasConcept C2779855799 @default.
• W2898032844 hasConcept C3018667095 @default.
• W2898032844 hasConcept C555293320 @default.
• W2898032844 hasConcept C71924100 @default.
• W2898032844 hasConcept C86803240 @default.
• W2898032844 hasConceptScore W2898032844C126322002 @default.

• next