FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898033484> ?p ?o ?g. }

• W2898033484 endingPage "5267" @default.
• W2898033484 startingPage "5256" @default.
• W2898033484 abstract "Abstract Endothelial progenitor cells (EPCs) are vital to the recovery of endothelial function and maintenance of vascular homeostasis. EPCs mobilize to sites of vessel injury and differentiate into mature endothelial cells (ECs). Locally mobilized EPCs are exposed to cyclic stretch caused by blood flow, which is important for EPC differentiation. MicroRNAs (miRNAs) have emerged as key regulators of several cellular processes. However, the role of miRNAs in cyclic stretch–induced EPC differentiation remains unclear. Here, we investigate the effects of microRNA‐129‐1‐3p (miR‐129‐1‐3p) and its novel target Runt‐related transcription factor 2 (Runx2) on EPC differentiation induced by cyclic stretch. Bone marrow‐derived EPCs were exposed to cyclic stretch with a magnitude of 5% (which mimics physiological mechanical stress) at a constant frequency of 1.25 Hz for 24 hours. The results from a miRNA array revealed that cyclic stretch significantly decreased miR‐129‐1‐3p expression. Furthermore, we found that downregulation of miR‐129‐1‐3p during cyclic stretch–induced EPC differentiation toward ECs. Meanwhile, expression of Runx2, a putative target gene of miR‐129‐1‐3p, was increased as a result of cyclic stretch. A 3′UTR reporter assay validated Runx2 as a direct target of miR‐129‐1‐3p. Furthermore, small interfering RNA (siRNA)‐mediated knockdown of Runx2 inhibited EPC differentiation into ECs and attenuated EPC tube formation via modulation of vascular endothelial growth factor (VEGF) secretion from EPCs in vitro. Our findings demonstrated that cyclic stretch suppresses miR‐129‐1‐3p expression, which in turn activates Runx2 and VEGF to promote endothelial differentiation of EPCs and angiogenesis. Therefore, targeting miR‐129‐1‐3p and Runx2 may be a potential therapeutic strategy for treating vessel injury." @default.
• W2898033484 created "2018-10-26" @default.
• W2898033484 creator A5001393741 @default.
• W2898033484 creator A5007461062 @default.
• W2898033484 creator A5031315906 @default.
• W2898033484 creator A5032396915 @default.
• W2898033484 creator A5039884371 @default.
• W2898033484 creator A5069167599 @default.
• W2898033484 creator A5076763918 @default.
• W2898033484 date "2018-10-15" @default.
• W2898033484 modified "2023-10-16" @default.
• W2898033484 title "MicroRNA‐129‐1‐3p regulates cyclic stretch–induced endothelial progenitor cell differentiation by targeting Runx2" @default.
• W2898033484 cites W1487286189 @default.
• W2898033484 cites W1542357680 @default.
• W2898033484 cites W1563563954 @default.
• W2898033484 cites W1927563535 @default.
• W2898033484 cites W1935034318 @default.
• W2898033484 cites W1971806567 @default.
• W2898033484 cites W1973215258 @default.
• W2898033484 cites W1976291192 @default.
• W2898033484 cites W1978561866 @default.
• W2898033484 cites W1980552126 @default.
• W2898033484 cites W1999532904 @default.
• W2898033484 cites W2002995168 @default.
• W2898033484 cites W2008023840 @default.
• W2898033484 cites W2010254234 @default.
• W2898033484 cites W2015542371 @default.
• W2898033484 cites W2021488944 @default.
• W2898033484 cites W2030166934 @default.
• W2898033484 cites W2030620933 @default.
• W2898033484 cites W2036442218 @default.
• W2898033484 cites W2053704719 @default.
• W2898033484 cites W2053908471 @default.
• W2898033484 cites W2054271984 @default.
• W2898033484 cites W2056686012 @default.
• W2898033484 cites W2060092038 @default.
• W2898033484 cites W2071890879 @default.
• W2898033484 cites W2083586858 @default.
• W2898033484 cites W2098667235 @default.
• W2898033484 cites W2101018118 @default.
• W2898033484 cites W2131762882 @default.
• W2898033484 cites W2131998303 @default.
• W2898033484 cites W2133404400 @default.
• W2898033484 cites W2135703884 @default.
• W2898033484 cites W2140642334 @default.
• W2898033484 cites W2145790583 @default.
• W2898033484 cites W2159384382 @default.
• W2898033484 cites W2163106706 @default.
• W2898033484 cites W2268214505 @default.
• W2898033484 cites W2293875071 @default.
• W2898033484 cites W2411534330 @default.
• W2898033484 cites W2548902544 @default.
• W2898033484 cites W2578505019 @default.
• W2898033484 cites W2594052307 @default.
• W2898033484 cites W2606204195 @default.
• W2898033484 cites W2616521597 @default.
• W2898033484 cites W2734216025 @default.
• W2898033484 cites W2737166218 @default.
• W2898033484 cites W2791142181 @default.
• W2898033484 doi "https://doi.org/10.1002/jcb.27800" @default.
• W2898033484 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30320897" @default.
• W2898033484 hasPublicationYear "2018" @default.
• W2898033484 type Work @default.
• W2898033484 sameAs 2898033484 @default.
• W2898033484 citedByCount "12" @default.
• W2898033484 countsByYear W28980334842019 @default.
• W2898033484 countsByYear W28980334842020 @default.
• W2898033484 countsByYear W28980334842021 @default.
• W2898033484 countsByYear W28980334842022 @default.
• W2898033484 countsByYear W28980334842023 @default.
• W2898033484 crossrefType "journal-article" @default.
• W2898033484 hasAuthorship W2898033484A5001393741 @default.
• W2898033484 hasAuthorship W2898033484A5007461062 @default.
• W2898033484 hasAuthorship W2898033484A5031315906 @default.
• W2898033484 hasAuthorship W2898033484A5032396915 @default.
• W2898033484 hasAuthorship W2898033484A5039884371 @default.
• W2898033484 hasAuthorship W2898033484A5069167599 @default.
• W2898033484 hasAuthorship W2898033484A5076763918 @default.
• W2898033484 hasConcept C104317684 @default.
• W2898033484 hasConcept C123012128 @default.
• W2898033484 hasConcept C127561419 @default.
• W2898033484 hasConcept C145059251 @default.
• W2898033484 hasConcept C148738053 @default.
• W2898033484 hasConcept C173396325 @default.
• W2898033484 hasConcept C185592680 @default.
• W2898033484 hasConcept C201750760 @default.
• W2898033484 hasConcept C202751555 @default.
• W2898033484 hasConcept C2776363554 @default.
• W2898033484 hasConcept C2780152582 @default.
• W2898033484 hasConcept C28328180 @default.
• W2898033484 hasConcept C55493867 @default.
• W2898033484 hasConcept C86339819 @default.
• W2898033484 hasConcept C86803240 @default.
• W2898033484 hasConcept C95444343 @default.
• W2898033484 hasConceptScore W2898033484C104317684 @default.
• W2898033484 hasConceptScore W2898033484C123012128 @default.
• W2898033484 hasConceptScore W2898033484C127561419 @default.
• W2898033484 hasConceptScore W2898033484C145059251 @default.

• next