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• W2898034847 abstract "Abstract Background In a large and comprehensively assessed sample of patients with bipolar disorder type I (BDI), we investigated the prevalence of psychotic features and their relationship with life course, demographic, clinical, and cognitive characteristics. We hypothesized that groups of psychotic symptoms (Schneiderian, mood incongruent, thought disorder, delusions, and hallucinations) have distinct relations to risk factors. Methods In a cross-sectional study of 1342 BDI patients, comprehensive demographical and clinical characteristics were assessed using the Structured Clinical Interview for DSM-IV (SCID-I) interview. In addition, levels of childhood maltreatment and intelligence quotient (IQ) were assessed. The relationships between these characteristics and psychotic symptoms were analyzed using multiple general linear models. Results A lifetime history of psychotic symptoms was present in 73.8% of BDI patients and included delusions in 68.9% of patients and hallucinations in 42.6%. Patients with psychotic symptoms showed a significant younger age of disease onset ( β = −0.09, t = −3.38, p = 0.001) and a higher number of hospitalizations for manic episodes ( F 11 338 = 56.53, p < 0.001). Total IQ was comparable between groups. Patients with hallucinations had significant higher levels of childhood maltreatment ( β = 0.09, t = 3.04, p = 0.002). Conclusions In this large cohort of BDI patients, the vast majority of patients had experienced psychotic symptoms. Psychotic symptoms in BDI were associated with an earlier disease onset and more frequent hospitalizations particularly for manic episodes. The study emphasizes the strength of the relation between childhood maltreatment and hallucinations but did not identify distinct subgroups based on psychotic features and instead reported of a large heterogeneity of psychotic symptoms in BD." @default.
• W2898034847 created "2018-10-26" @default.
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• W2898034847 date "2018-10-10" @default.
• W2898034847 modified "2023-10-18" @default.
• W2898034847 title "The characteristics of psychotic features in bipolar disorder" @default.
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• W2898034847 doi "https://doi.org/10.1017/s0033291718002854" @default.
• W2898034847 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30303059" @default.
• W2898034847 hasPublicationYear "2018" @default.
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