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- W2898035302 abstract "One-pot synthesis of novel quinoline- and quinolone-substituted 1,2,3-triazoles has been performed from the key intermediates, quinoline- and quinolone-substituted propargyl derivatives 1-3 (48%-88% yields). The antioxidant properties of the newly synthesized compounds, 1a-1c, 2a-2c, and 3a-3c, were evaluated by monitoring DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging abilities, metal chelating effects, and reducing power. The scavenging effects of compounds on the free radical decreased in the order of 3b$>$ 3a$>$ 1b} and were found to be 36.3%, 34.9%, and 27.6% at the concentration of 500 $mu $g/mL, respectively. All of the compounds showed low chelating capacity. Furthermore, the antibacterial activity was studied against gram-positive and gram-negative bacteria and the DNA binding ability of the compounds was evaluated with calf thymus DNA using agarose gel electrophoresis." @default.
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- W2898035302 date "2018-10-11" @default.
- W2898035302 modified "2023-09-29" @default.
- W2898035302 title "Synthesis and biological evaluation of quinoline-triazole and quinolone-triazole conjugates" @default.
- W2898035302 doi "https://doi.org/10.3906/kim-1804-18" @default.
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