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- W2898039922 abstract "Widespread cerebral amyloid angiopathy (CAA) has been suggested to contribute to neuronal dysfunction in AD. Nevertheless, the pathological coexistence of AD and CAA makes it difficult to judge the contribution of CAA to AD progression. Pure CAA model mice are desired. In order to develop CAA model mice that specifically express human APP Swedish mutation (NL) in the endothelial cells, we first generated conditional transgenic mice harboring loxP-neo(R)-loxP-APP770NL, (APP770NL(flox)). We then crossed the mice with Tie2-Cre mice that specifically express Cre recombinase in their endothelial cells. We found that aged but not young mice expressing the human APP770NL specifically in endothelial cells exhibit amyloid-b (Ab) deposition in brain vessels but not the parenchyma. Remarkably, not all but some of the aged transgenic mice shows cerebral hemorrhage. These findings highlight the contribution of endothelial APP770 to vascular Ab deposition. We also show that glycosylation of endothelial APP is a critical regulator of its intracellular trafficking and Ab generation." @default.
- W2898039922 created "2018-10-26" @default.
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- W2898039922 date "2018-07-01" @default.
- W2898039922 modified "2023-10-16" @default.
- W2898039922 title "P1‐207: ENDOTHELIAL APP EXPRESSION LEADS TO CEREBRAL AMYLOID ANGIOPATHY IN VIVO" @default.
- W2898039922 doi "https://doi.org/10.1016/j.jalz.2018.06.212" @default.
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