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- W2898040340 abstract "Introduction Intracerebral hemorrhage (ICH) is a lethal cerebrovascular disorder with a high mortality and morbidity. The pathophysiological mechanisms underlying ICH-induced secondary injury remain unclear. Methods To examine one of the gaps in the knowledge about ICH pathological mechanisms, isobaric tag for relative and absolute quantification (iTRAQ)-based liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used in collagenase-induced ICH rats on the 2nd day. Results A total of 6,456 proteins were identified with a 1% false discovery rate (FDR). Of these proteins, 126 and 75 differentially expressed proteins (DEPs) were substantially increased and decreased, respectively. Based on Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and STRING analyses, the protein changes in cerebral hemorrhage were comprehensively evaluated, and the energy metabolism in ICH was anchored. The core position of the nitrogen metabolism pathway in brain metabolism in ICH was found for the first time. Carbonic anhydrase 1 (Ca1), carbonic anhydrase 2 (Ca2), and glutamine synthetase (Glul) participated in this pathway. We constructed the protein–protein interaction (PPI) networks for the energy metabolism of ICH, including the Atp6v1a-Atp6v0c-Atp6v0d1-Ppa2-Atp6ap2 network. Conclusions It seems that dysregulation of energy metabolism, especially nitrogen metabolism, may be a major cause in secondary ICH injury. This information provides novel insights into secondary events following ICH." @default.
- W2898040340 created "2018-10-26" @default.
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- W2898040340 date "2018-10-11" @default.
- W2898040340 modified "2023-10-16" @default.
- W2898040340 title "Quantitative proteomic analysis of intracerebral hemorrhage in rats with a focus on brain energy metabolism" @default.
- W2898040340 cites W1508637318 @default.
- W2898040340 cites W1511344577 @default.
- W2898040340 cites W1911175850 @default.
- W2898040340 cites W1947800747 @default.
- W2898040340 cites W1968092825 @default.
- W2898040340 cites W1968545758 @default.
- W2898040340 cites W1968947739 @default.
- W2898040340 cites W1984530522 @default.
- W2898040340 cites W1991334711 @default.
- W2898040340 cites W1992788998 @default.
- W2898040340 cites W1995943575 @default.
- W2898040340 cites W1998191794 @default.
- W2898040340 cites W1999818224 @default.
- W2898040340 cites W2000551557 @default.
- W2898040340 cites W2005468750 @default.
- W2898040340 cites W2008366009 @default.
- W2898040340 cites W2010526081 @default.
- W2898040340 cites W2012206724 @default.
- W2898040340 cites W2014753251 @default.
- W2898040340 cites W2024343314 @default.
- W2898040340 cites W2030677245 @default.
- W2898040340 cites W2034336002 @default.
- W2898040340 cites W2040181826 @default.
- W2898040340 cites W2042768109 @default.
- W2898040340 cites W2049262684 @default.
- W2898040340 cites W2051433943 @default.
- W2898040340 cites W2057750534 @default.
- W2898040340 cites W2074216751 @default.
- W2898040340 cites W2074906955 @default.
- W2898040340 cites W2076944509 @default.
- W2898040340 cites W2079074836 @default.
- W2898040340 cites W2080860795 @default.
- W2898040340 cites W2083638799 @default.
- W2898040340 cites W2086628740 @default.
- W2898040340 cites W2087292928 @default.
- W2898040340 cites W2087322129 @default.
- W2898040340 cites W2106305657 @default.
- W2898040340 cites W2116505148 @default.
- W2898040340 cites W2118695506 @default.
- W2898040340 cites W2120290958 @default.
- W2898040340 cites W2136587148 @default.
- W2898040340 cites W2142511211 @default.
- W2898040340 cites W2150002111 @default.
- W2898040340 cites W2157839186 @default.
- W2898040340 cites W2168270559 @default.
- W2898040340 cites W218958693 @default.
- W2898040340 cites W2214900079 @default.
- W2898040340 cites W2279646291 @default.
- W2898040340 cites W2284438769 @default.
- W2898040340 cites W2288990009 @default.
- W2898040340 cites W2294300560 @default.
- W2898040340 cites W2339455913 @default.
- W2898040340 cites W2343783270 @default.
- W2898040340 cites W2344082772 @default.
- W2898040340 cites W2390578510 @default.
- W2898040340 cites W2413525939 @default.
- W2898040340 cites W2470016165 @default.
- W2898040340 cites W2471456962 @default.
- W2898040340 cites W2514744505 @default.
- W2898040340 cites W2517353926 @default.
- W2898040340 cites W2552912919 @default.
- W2898040340 cites W2554599497 @default.
- W2898040340 cites W2556985739 @default.
- W2898040340 cites W2562815196 @default.
- W2898040340 cites W2565330593 @default.
- W2898040340 cites W2584082995 @default.
- W2898040340 cites W2604481254 @default.
- W2898040340 cites W2615735913 @default.
- W2898040340 cites W2619122250 @default.
- W2898040340 cites W2625766497 @default.
- W2898040340 cites W2732178602 @default.
- W2898040340 cites W2746230988 @default.
- W2898040340 cites W3171831654 @default.
- W2898040340 cites W587242119 @default.
- W2898040340 cites W6908103 @default.
- W2898040340 cites W797202421 @default.
- W2898040340 doi "https://doi.org/10.1002/brb3.1130" @default.
- W2898040340 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6236229" @default.
- W2898040340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30307711" @default.
- W2898040340 hasPublicationYear "2018" @default.
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