Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898044585> ?p ?o ?g. }
- W2898044585 endingPage "11143" @default.
- W2898044585 startingPage "11129" @default.
- W2898044585 abstract "H2B ubiquitylation (H2Bub)-dependent H3K4 methylation is mediated by the multisubunit Set1 complex (Set1C) in yeast, but precisely how Set1C subunits contribute to this histone modification remains unclear. Here, using reconstituted Set1Cs and recombinant H2Bub chromatin, we identified Set1C subunits and domains involved in the H2Bub-dependent H3K4 methylation process, showing that the Spp1 PHDL domain, in conjunction with the Set1 n-SET domain, interacts with Swd1/Swd3 and that this interaction is essential for H2Bub-dependent H3K4 methylation. Importantly, Set1C containing an Spp1-Swd1 fusion bypasses the requirement for H2Bub for H3K4 methylation, suggesting that the role of H2Bub is to induce allosteric rearrangements of the subunit-interaction network within the active site of Set1C that are necessary for methylation activity. Moreover, the interaction between the Set1 N-terminal region and Swd1 renders the Spp1-lacking Set1C competent for H2Bub-dependent H3K4 methylation. Collectively, our results suggest that H2Bub induces conformational changes in Set1C that support H3K4 methylation activity." @default.
- W2898044585 created "2018-10-26" @default.
- W2898044585 creator A5019083787 @default.
- W2898044585 creator A5029842844 @default.
- W2898044585 creator A5031060352 @default.
- W2898044585 creator A5055015781 @default.
- W2898044585 creator A5075707554 @default.
- W2898044585 date "2018-10-16" @default.
- W2898044585 modified "2023-10-16" @default.
- W2898044585 title "Crosstalk among Set1 complex subunits involved in H2B ubiquitylation-dependent H3K4 methylation" @default.
- W2898044585 cites W1715660697 @default.
- W2898044585 cites W1963996414 @default.
- W2898044585 cites W1969671007 @default.
- W2898044585 cites W1974005787 @default.
- W2898044585 cites W1979670780 @default.
- W2898044585 cites W1980008053 @default.
- W2898044585 cites W1982498507 @default.
- W2898044585 cites W1991487490 @default.
- W2898044585 cites W1995673646 @default.
- W2898044585 cites W2007977711 @default.
- W2898044585 cites W2009403023 @default.
- W2898044585 cites W2009504090 @default.
- W2898044585 cites W2009858080 @default.
- W2898044585 cites W2010790480 @default.
- W2898044585 cites W2023096418 @default.
- W2898044585 cites W2023348831 @default.
- W2898044585 cites W2030197516 @default.
- W2898044585 cites W2036479240 @default.
- W2898044585 cites W2045665004 @default.
- W2898044585 cites W2050690313 @default.
- W2898044585 cites W2051163721 @default.
- W2898044585 cites W2070959297 @default.
- W2898044585 cites W2072579569 @default.
- W2898044585 cites W2092038358 @default.
- W2898044585 cites W2108014213 @default.
- W2898044585 cites W2118542750 @default.
- W2898044585 cites W2118916005 @default.
- W2898044585 cites W2121910267 @default.
- W2898044585 cites W2127034275 @default.
- W2898044585 cites W2145502498 @default.
- W2898044585 cites W2148940587 @default.
- W2898044585 cites W2156534307 @default.
- W2898044585 cites W2161006357 @default.
- W2898044585 cites W2299661313 @default.
- W2898044585 cites W2345109029 @default.
- W2898044585 cites W2551929191 @default.
- W2898044585 cites W2607585298 @default.
- W2898044585 cites W2612768962 @default.
- W2898044585 cites W2751712711 @default.
- W2898044585 cites W2766340225 @default.
- W2898044585 cites W2767770944 @default.
- W2898044585 cites W2787000623 @default.
- W2898044585 cites W2886127471 @default.
- W2898044585 cites W2886836393 @default.
- W2898044585 doi "https://doi.org/10.1093/nar/gky920" @default.
- W2898044585 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6265457" @default.
- W2898044585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30325428" @default.
- W2898044585 hasPublicationYear "2018" @default.
- W2898044585 type Work @default.
- W2898044585 sameAs 2898044585 @default.
- W2898044585 citedByCount "15" @default.
- W2898044585 countsByYear W28980445852019 @default.
- W2898044585 countsByYear W28980445852020 @default.
- W2898044585 countsByYear W28980445852021 @default.
- W2898044585 countsByYear W28980445852022 @default.
- W2898044585 countsByYear W28980445852023 @default.
- W2898044585 crossrefType "journal-article" @default.
- W2898044585 hasAuthorship W2898044585A5019083787 @default.
- W2898044585 hasAuthorship W2898044585A5029842844 @default.
- W2898044585 hasAuthorship W2898044585A5031060352 @default.
- W2898044585 hasAuthorship W2898044585A5055015781 @default.
- W2898044585 hasAuthorship W2898044585A5075707554 @default.
- W2898044585 hasBestOaLocation W28980445851 @default.
- W2898044585 hasConcept C104292427 @default.
- W2898044585 hasConcept C104317684 @default.
- W2898044585 hasConcept C120665830 @default.
- W2898044585 hasConcept C121332964 @default.
- W2898044585 hasConcept C150194340 @default.
- W2898044585 hasConcept C169822122 @default.
- W2898044585 hasConcept C190727270 @default.
- W2898044585 hasConcept C22709980 @default.
- W2898044585 hasConcept C33288867 @default.
- W2898044585 hasConcept C41091548 @default.
- W2898044585 hasConcept C54355233 @default.
- W2898044585 hasConcept C552990157 @default.
- W2898044585 hasConcept C64927066 @default.
- W2898044585 hasConcept C83640560 @default.
- W2898044585 hasConcept C86803240 @default.
- W2898044585 hasConcept C95444343 @default.
- W2898044585 hasConceptScore W2898044585C104292427 @default.
- W2898044585 hasConceptScore W2898044585C104317684 @default.
- W2898044585 hasConceptScore W2898044585C120665830 @default.
- W2898044585 hasConceptScore W2898044585C121332964 @default.
- W2898044585 hasConceptScore W2898044585C150194340 @default.
- W2898044585 hasConceptScore W2898044585C169822122 @default.
- W2898044585 hasConceptScore W2898044585C190727270 @default.
- W2898044585 hasConceptScore W2898044585C22709980 @default.
- W2898044585 hasConceptScore W2898044585C33288867 @default.