FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898047292> ?p ?o ?g. }

• W2898047292 abstract "Author(s): Gold, Eric | Advisor(s): Cummings, Brian | Abstract: Every year, there are 3.8 million traumatic brain injuries in the United States leading to an estimated 5.3 million Americans that are currently living with a disability due to these injuries. Of these traumatic brain injuries (TBI), 75% are considered to be mild in severity. Importantly, while a single mild TBI has transient symptoms and associated neuropathological features, multiple mild TBI can result in a wide range of debilitating chronic symptoms and neuropathological features. Laboratory rodent models of traumatic brain injury have primarily focused on acute outcomes following TBI, and have also not focused heavily on repeated mild closed head injuries. This dissertation first reviews the literature outlining rodent models of traumatic brain injury, and the lack of assessments at chronic timepoints following injury. We found that 68% of papers did not evaluate a functional outcome past 1-month post TBI, and 90% of papers reviewed did not make a functional assessment 2 or more months following injury. Of these papers that investigated a 2 month timepoint, 84% demonstrated a functional deficit in a behavioral measure, stressing the persistence of chronic deficits and the important of studying them. Next, we focus on the development of a rodent model of repeated mild traumatic brain injury. We utilized components of classic rodent models of TBI to develop a model and protocol for repeated mild closed head injuries (rmCHI) that can be easily reproduced across users and laboratories, and mimics the clinical presentation. The parameters of our model of rmCHI produce behavioral changes and neuropathological features for multiple impacts, but not single impacts, at chronic timepoints of 1, 2, and 6 months post injury. Behavioral changes in measures of anxiety, depression, and learning are also closely associated with neuropathological features including white matter atrophy and cortical neuronal loss. rmCHI results in 33-35% corpus callosum loss, developing by 2 months and lasting out to 6 months post injury. Lastly, we dive deeper into the mechanisms underlying white matter loss, test more mild injury parameters to find injury thresholds, test rmCHI in an immunocompromised mouse strain, and explore potential novel therapeutics for rmCHI." @default.
• W2898047292 created "2018-10-26" @default.
• W2898047292 creator A5084209838 @default.
• W2898047292 date "2017-01-01" @default.
• W2898047292 modified "2023-09-26" @default.
• W2898047292 title "Chronic Behavioral Changes and Associated Neuropathological Features In a Rodent Model of Repeated Mild Traumatic Brain Injury" @default.
• W2898047292 hasPublicationYear "2017" @default.
• W2898047292 type Work @default.
• W2898047292 sameAs 2898047292 @default.
• W2898047292 citedByCount "0" @default.
• W2898047292 crossrefType "journal-article" @default.
• W2898047292 hasAuthorship W2898047292A5084209838 @default.
• W2898047292 hasConcept C118552586 @default.
• W2898047292 hasConcept C126322002 @default.
• W2898047292 hasConcept C15744967 @default.
• W2898047292 hasConcept C190385971 @default.
• W2898047292 hasConcept C2777975874 @default.
• W2898047292 hasConcept C2778426673 @default.
• W2898047292 hasConcept C2779818104 @default.
• W2898047292 hasConcept C2781017439 @default.
• W2898047292 hasConcept C2911139526 @default.
• W2898047292 hasConcept C2992558993 @default.
• W2898047292 hasConcept C3017944768 @default.
• W2898047292 hasConcept C545542383 @default.
• W2898047292 hasConcept C71924100 @default.
• W2898047292 hasConcept C99508421 @default.
• W2898047292 hasConceptScore W2898047292C118552586 @default.
• W2898047292 hasConceptScore W2898047292C126322002 @default.
• W2898047292 hasConceptScore W2898047292C15744967 @default.
• W2898047292 hasConceptScore W2898047292C190385971 @default.
• W2898047292 hasConceptScore W2898047292C2777975874 @default.
• W2898047292 hasConceptScore W2898047292C2778426673 @default.
• W2898047292 hasConceptScore W2898047292C2779818104 @default.
• W2898047292 hasConceptScore W2898047292C2781017439 @default.
• W2898047292 hasConceptScore W2898047292C2911139526 @default.
• W2898047292 hasConceptScore W2898047292C2992558993 @default.
• W2898047292 hasConceptScore W2898047292C3017944768 @default.
• W2898047292 hasConceptScore W2898047292C545542383 @default.
• W2898047292 hasConceptScore W2898047292C71924100 @default.
• W2898047292 hasConceptScore W2898047292C99508421 @default.
• W2898047292 hasLocation W28980472921 @default.
• W2898047292 hasOpenAccess W2898047292 @default.
• W2898047292 hasPrimaryLocation W28980472921 @default.
• W2898047292 hasRelatedWork W1503096084 @default.
• W2898047292 hasRelatedWork W1566362646 @default.
• W2898047292 hasRelatedWork W175281218 @default.
• W2898047292 hasRelatedWork W2015233826 @default.
• W2898047292 hasRelatedWork W2099118977 @default.
• W2898047292 hasRelatedWork W2278809101 @default.
• W2898047292 hasRelatedWork W2438675525 @default.
• W2898047292 hasRelatedWork W2487395313 @default.
• W2898047292 hasRelatedWork W2606167544 @default.
• W2898047292 hasRelatedWork W2791082558 @default.
• W2898047292 hasRelatedWork W2895740786 @default.
• W2898047292 hasRelatedWork W2898587029 @default.
• W2898047292 hasRelatedWork W2900465297 @default.
• W2898047292 hasRelatedWork W2931442982 @default.
• W2898047292 hasRelatedWork W2963317484 @default.
• W2898047292 hasRelatedWork W2980353042 @default.
• W2898047292 hasRelatedWork W3120842994 @default.
• W2898047292 hasRelatedWork W3161051644 @default.
• W2898047292 hasRelatedWork W3206536823 @default.
• W2898047292 hasRelatedWork W2003025900 @default.
• W2898047292 isParatext "false" @default.
• W2898047292 isRetracted "false" @default.
• W2898047292 magId "2898047292" @default.
• W2898047292 workType "article" @default.