FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898047763> ?p ?o ?g. }

• W2898047763 endingPage "438" @default.
• W2898047763 startingPage "425" @default.
• W2898047763 abstract "Background and Objectives: Leishmaniasis has created global health problems in the developing countries with high endemicity such as Iran. Drug side effects and resistance and the lack of effective and safe vaccine have caused the new effective compounds from medicinal plants such as purslane to be attended. Therefore, the aim of this study was to introduce purslane as a traditional medicinal plant, which can be taken into consideration as a valuable source of new pharmaceutical agents against cutaneous leishmaniasis. Material and Methods: This is a laboratory study conducted in Isfahan in the spring of 2015. In the first place, the methanol extract was prepared by soaking method and its combination was determined by mass chromatography gas method. L. major promastigotes were cultured in Schneider culture media and in the stationary phase in RPMI-1640 medium, respectively. Then, using colorimetric MTT (methyl thiazolyl tetrazolium), the biological activity of alcoholic extract of purslane against L. major promastigotes was assessed in comparison to meglumine. The data were analyzed by the Tukey test and t-test using software SPSS16. Microscopic study results were presented as images and tables. Resalts: IC50 for alcoholic extract of purslane against standard L. major promastigotes after 24, 48 and 72 hours were 690, 270 and 140 micrograms per mililiter and against clinical isolates of promastigotes of 1160, 385 and 140 micrograms per milliliter, respectively. IC50 for Glucantime equaled to 27, 12 and 8 micrograms per ml and 26, 19 and 11 micrograms per milliliter, respectively. There was a significant difference between the IC50 extract and glucantime drug after 24, 48 and 72 hours (p less-than 0.05). There was observed cell shrinkage, roundness, compressed cytoplasm and smallness in the treated cells. Presence of alkaloids and flavonoids were detected in the alcoholic extract. Conclusion: In regard to alcoholic extract of purslane had considerable anti-leishmanial effect in vitro, conducting more experiments to investigate its effect on the parasite in animal model also seems to be necessary. Key words: Antileishmanial compounds, Cutaneous Leishmaniasis, Methyl Tiasolyl Tetrasolium Funding: The authors and Isfahan Seddigheh Tahereh Research Laboratory of Infectious and Tropical Diseases Conflict of interest: None declared. Ethical approval: The ethics Committee of Isfahan Seddigheh Tahereh Research Laboratory of Infectious and Tropical Diseases How to cite this article: Gharirvand Eskandari E, Doudi M. The Study of Composition and Antileishmanial Effect of Portulaca Oleracea Aerial Organs Hydroalcoholic Extract on Leishmania Major (Mrho/Ir/75/Er) and a Clinical Isolate in Vitro. J Rafsanjan Univ Med Sci 2016; 15(5):425-38. [Farsi]" @default.
• W2898047763 created "2018-10-26" @default.
• W2898047763 creator A5005194279 @default.
• W2898047763 creator A5012040467 @default.
• W2898047763 date "2016-09-10" @default.
• W2898047763 modified "2023-10-09" @default.
• W2898047763 title "The Study of Composition and Anti-leishmanial Effect of Portulaca Oleracea Aerial Organs Hydroalcoholic Extract on Leishmania Major (Mrho/Ir/75/Er) and A Clinical Isolate In Vitro" @default.
• W2898047763 cites W1629179716 @default.
• W2898047763 cites W1845083672 @default.
• W2898047763 cites W1978243510 @default.
• W2898047763 cites W1980191878 @default.
• W2898047763 cites W2001579835 @default.
• W2898047763 cites W2037063107 @default.
• W2898047763 cites W2073640782 @default.
• W2898047763 cites W2227988821 @default.
• W2898047763 cites W2288649994 @default.
• W2898047763 cites W2301267358 @default.
• W2898047763 cites W2301598366 @default.
• W2898047763 hasPublicationYear "2016" @default.
• W2898047763 type Work @default.
• W2898047763 sameAs 2898047763 @default.
• W2898047763 citedByCount "0" @default.
• W2898047763 crossrefType "journal-article" @default.
• W2898047763 hasAuthorship W2898047763A5005194279 @default.
• W2898047763 hasAuthorship W2898047763A5012040467 @default.
• W2898047763 hasConcept C136764020 @default.
• W2898047763 hasConcept C202751555 @default.
• W2898047763 hasConcept C203014093 @default.
• W2898047763 hasConcept C2776555147 @default.
• W2898047763 hasConcept C2777752497 @default.
• W2898047763 hasConcept C2780383148 @default.
• W2898047763 hasConcept C2780783641 @default.
• W2898047763 hasConcept C2781092759 @default.
• W2898047763 hasConcept C33070731 @default.
• W2898047763 hasConcept C41008148 @default.
• W2898047763 hasConcept C42972112 @default.
• W2898047763 hasConcept C55493867 @default.
• W2898047763 hasConcept C556039675 @default.
• W2898047763 hasConcept C71924100 @default.
• W2898047763 hasConcept C71928629 @default.
• W2898047763 hasConcept C86803240 @default.
• W2898047763 hasConcept C96529984 @default.
• W2898047763 hasConceptScore W2898047763C136764020 @default.
• W2898047763 hasConceptScore W2898047763C202751555 @default.
• W2898047763 hasConceptScore W2898047763C203014093 @default.
• W2898047763 hasConceptScore W2898047763C2776555147 @default.
• W2898047763 hasConceptScore W2898047763C2777752497 @default.
• W2898047763 hasConceptScore W2898047763C2780383148 @default.
• W2898047763 hasConceptScore W2898047763C2780783641 @default.
• W2898047763 hasConceptScore W2898047763C2781092759 @default.
• W2898047763 hasConceptScore W2898047763C33070731 @default.
• W2898047763 hasConceptScore W2898047763C41008148 @default.
• W2898047763 hasConceptScore W2898047763C42972112 @default.
• W2898047763 hasConceptScore W2898047763C55493867 @default.
• W2898047763 hasConceptScore W2898047763C556039675 @default.
• W2898047763 hasConceptScore W2898047763C71924100 @default.
• W2898047763 hasConceptScore W2898047763C71928629 @default.
• W2898047763 hasConceptScore W2898047763C86803240 @default.
• W2898047763 hasConceptScore W2898047763C96529984 @default.
• W2898047763 hasIssue "5" @default.
• W2898047763 hasLocation W28980477631 @default.
• W2898047763 hasOpenAccess W2898047763 @default.
• W2898047763 hasPrimaryLocation W28980477631 @default.
• W2898047763 hasRelatedWork W1568027126 @default.
• W2898047763 hasRelatedWork W1964706364 @default.
• W2898047763 hasRelatedWork W2100196421 @default.
• W2898047763 hasRelatedWork W2103162575 @default.
• W2898047763 hasRelatedWork W2113209548 @default.
• W2898047763 hasRelatedWork W2118592167 @default.
• W2898047763 hasRelatedWork W2163663729 @default.
• W2898047763 hasRelatedWork W2186510586 @default.
• W2898047763 hasRelatedWork W260216724 @default.
• W2898047763 hasRelatedWork W2614251230 @default.
• W2898047763 hasRelatedWork W2641369061 @default.
• W2898047763 hasRelatedWork W2789321047 @default.
• W2898047763 hasRelatedWork W2904783128 @default.
• W2898047763 hasRelatedWork W2972523256 @default.
• W2898047763 hasRelatedWork W2981655559 @default.
• W2898047763 hasRelatedWork W3034650938 @default.
• W2898047763 hasRelatedWork W3088193805 @default.
• W2898047763 hasRelatedWork W3102485187 @default.
• W2898047763 hasRelatedWork W3134511528 @default.
• W2898047763 hasRelatedWork W3204514183 @default.
• W2898047763 hasVolume "15" @default.
• W2898047763 isParatext "false" @default.
• W2898047763 isRetracted "false" @default.
• W2898047763 magId "2898047763" @default.
• W2898047763 workType "article" @default.