FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898049355> ?p ?o ?g. }

• W2898049355 endingPage "606" @default.
• W2898049355 startingPage "601" @default.
• W2898049355 abstract "Allogeneic SCT for older patients remains challenging at least in part due to graft-versus-host disease (GVHD) and higher non-relapse mortality (NRM). We conducted a prospective pilot study primarily for older patients undergoing matched unrelated donor (MUD) SCT using a reduced-intensity (RIC) melphalan-based conditioning and post-transplant cyclophosphamide (PTCy)-based GVHD prophylaxis with tacrolimus and mycophenolate mofetil. Twenty-two patients (median age 64, IQR 58, 66) underwent RIC MUD SCT for high-risk hematological malignancies including AML/MDS (73%), CML/MPD (18%), and other (10%). Two (9%) patients had early death; the rest (100%) engrafted. After a median follow-up of 17 months, 11 patients were alive and disease-free with an estimated 2-year progression-free (PFS) and overall (OS) survival of 48%. The cumulative incidences of grades 2-4 and 3-4 acute GVHD (aGVHD) at day + 100 and 2-years were 32 and 4%, and 59 and 24%, respectively. No cases of chronic GVHD (cGVHD) were noted. However, late acute GVHD was observed in 6 (27%) patients. In conclusion, RIC MUD SCT with melphalan-based conditioning and PTCy-based GVHD-based prophylaxis for older patients appears effective in controlling relapse. While cGVHD was not seen and early aGVHD appears controllable, a significant proportion developed late aGVHD responsible for higher NRM seen in these patients." @default.
• W2898049355 created "2018-10-26" @default.
• W2898049355 creator A5015342719 @default.
• W2898049355 creator A5016928938 @default.
• W2898049355 creator A5020872528 @default.
• W2898049355 creator A5026422612 @default.
• W2898049355 creator A5033737136 @default.
• W2898049355 creator A5034104852 @default.
• W2898049355 creator A5047522685 @default.
• W2898049355 creator A5048913229 @default.
• W2898049355 creator A5050962913 @default.
• W2898049355 creator A5055067812 @default.
• W2898049355 creator A5062428979 @default.
• W2898049355 creator A5066894053 @default.
• W2898049355 creator A5069460930 @default.
• W2898049355 creator A5085076031 @default.
• W2898049355 creator A5088175930 @default.
• W2898049355 creator A5091083304 @default.
• W2898049355 date "2018-10-18" @default.
• W2898049355 modified "2023-10-06" @default.
• W2898049355 title "Pilot study using post-transplant cyclophosphamide (PTCy), tacrolimus and mycophenolate GVHD prophylaxis for older patients receiving 10/10 HLA-matched unrelated donor hematopoietic stem cell transplantation" @default.
• W2898049355 cites W1492609361 @default.
• W2898049355 cites W1926130940 @default.
• W2898049355 cites W1973617793 @default.
• W2898049355 cites W1980180443 @default.
• W2898049355 cites W1982767302 @default.
• W2898049355 cites W2017000328 @default.
• W2898049355 cites W2020172209 @default.
• W2898049355 cites W2035592289 @default.
• W2898049355 cites W2038981426 @default.
• W2898049355 cites W2048306988 @default.
• W2898049355 cites W2055553511 @default.
• W2898049355 cites W2064789340 @default.
• W2898049355 cites W2069262493 @default.
• W2898049355 cites W2125080520 @default.
• W2898049355 cites W2128812336 @default.
• W2898049355 cites W2152591595 @default.
• W2898049355 cites W2169530433 @default.
• W2898049355 cites W2234309584 @default.
• W2898049355 cites W2242834385 @default.
• W2898049355 cites W2481464774 @default.
• W2898049355 cites W2519813445 @default.
• W2898049355 cites W2538647664 @default.
• W2898049355 cites W2570618306 @default.
• W2898049355 cites W2746503114 @default.
• W2898049355 cites W2755189167 @default.
• W2898049355 cites W2800808649 @default.
• W2898049355 cites W2802852182 @default.
• W2898049355 doi "https://doi.org/10.1038/s41409-018-0367-2" @default.
• W2898049355 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7232773" @default.
• W2898049355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30337700" @default.
• W2898049355 hasPublicationYear "2018" @default.
• W2898049355 type Work @default.
• W2898049355 sameAs 2898049355 @default.
• W2898049355 citedByCount "24" @default.
• W2898049355 countsByYear W28980493552019 @default.
• W2898049355 countsByYear W28980493552020 @default.
• W2898049355 countsByYear W28980493552021 @default.
• W2898049355 countsByYear W28980493552022 @default.
• W2898049355 countsByYear W28980493552023 @default.
• W2898049355 crossrefType "journal-article" @default.
• W2898049355 hasAuthorship W2898049355A5015342719 @default.
• W2898049355 hasAuthorship W2898049355A5016928938 @default.
• W2898049355 hasAuthorship W2898049355A5020872528 @default.
• W2898049355 hasAuthorship W2898049355A5026422612 @default.
• W2898049355 hasAuthorship W2898049355A5033737136 @default.
• W2898049355 hasAuthorship W2898049355A5034104852 @default.
• W2898049355 hasAuthorship W2898049355A5047522685 @default.
• W2898049355 hasAuthorship W2898049355A5048913229 @default.
• W2898049355 hasAuthorship W2898049355A5050962913 @default.
• W2898049355 hasAuthorship W2898049355A5055067812 @default.
• W2898049355 hasAuthorship W2898049355A5062428979 @default.
• W2898049355 hasAuthorship W2898049355A5066894053 @default.
• W2898049355 hasAuthorship W2898049355A5069460930 @default.
• W2898049355 hasAuthorship W2898049355A5085076031 @default.
• W2898049355 hasAuthorship W2898049355A5088175930 @default.
• W2898049355 hasAuthorship W2898049355A5091083304 @default.
• W2898049355 hasBestOaLocation W28980493551 @default.
• W2898049355 hasConcept C126322002 @default.
• W2898049355 hasConcept C141071460 @default.
• W2898049355 hasConcept C2776694085 @default.
• W2898049355 hasConcept C2776755627 @default.
• W2898049355 hasConcept C2777408962 @default.
• W2898049355 hasConcept C2778684742 @default.
• W2898049355 hasConcept C2779972918 @default.
• W2898049355 hasConcept C2909675724 @default.
• W2898049355 hasConcept C2911091166 @default.
• W2898049355 hasConcept C71924100 @default.
• W2898049355 hasConcept C90924648 @default.
• W2898049355 hasConceptScore W2898049355C126322002 @default.
• W2898049355 hasConceptScore W2898049355C141071460 @default.
• W2898049355 hasConceptScore W2898049355C2776694085 @default.
• W2898049355 hasConceptScore W2898049355C2776755627 @default.
• W2898049355 hasConceptScore W2898049355C2777408962 @default.
• W2898049355 hasConceptScore W2898049355C2778684742 @default.
• W2898049355 hasConceptScore W2898049355C2779972918 @default.
• W2898049355 hasConceptScore W2898049355C2909675724 @default.
• W2898049355 hasConceptScore W2898049355C2911091166 @default.

• next