FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898049860> ?p ?o ?g. }

• W2898049860 endingPage "e651" @default.
• W2898049860 startingPage "e650" @default.
• W2898049860 abstract "We investigated the effect of radiotherapy modality for Federation of Gynecology and Obstetrics (FIGO) stage II endometrial cancer after hysterectomy using the National Cancer Database (NCDB). Between 2004 and 2013, FIGO Stage II endometrial cancer patients who received a total, modified radical or extended hysterectomy were selected from the NCDB. Patients with positive margins were excluded. Adenocarcinoma, clear cell, and papillary serous histological subtypes were allowed. Differences in outcomes between patients who received external beam radiation (EBRT), vaginal brachytherapy (VBT), or both (EBRT+VBT) were investigated. Lymph node number removed and receipt of chemotherapy were also examined. The primary endpoint of this study was overall survival (OS). A total of 4,497 patients were eligible for analysis with a median follow-up of 47.8 months and median age of 62. Adenocarcinomas comprised 88.4% of the population, and 66.0% received radiation, with 16.8% receiving chemotherapy. Univariate analysis revealed race, Charlson-Deyo Score (performance status), grade, lymphovascular invasion (LVSI), receipt of radiation, lymph node number removed (<10 vs ≥10), and age to each be significant for OS (p<0.01). On multivariable analysis (MVA) of all patients, African-American (vs White) race, not receiving radiation, Charlson-Deyo Score 2, grade 2-3 cancer (vs grade 1), <10 lymph nodes resected, and older age were associated (p < 0.01) with worse OS. Of patients who received radiation, VBT was associated with a significantly improved OS (p=0.03) when compared to EBRT (HR 1.38, 95% CI 1.10-1.73) or EBRT+VBT (HR 1.25, 95% CI 1.02-1.54). On MVA of those who received radiation, no differences in OS were observed between VBT (HR 1.00), EBRT (HR 1.11, 95% CI 0.86-1.41), or EBRT+VBT (HR 1.08, 95% CI 0.86-1.36), and chemotherapy was not associated with improved OS (HR 0.82, 95% CI 0.63-1.07, p = 0.14). When evaluating individual patient cohorts separated by grade and radiation therapy modality, there existed no difference in 5 year OS between groups (p=0.74). On stratification by presence of LVSI and radiation modality, there was no difference in 5 year OS when comparing each individual group (p=0.4). This study suggests that adjuvant radiation plays a key role in the management of operable Stage II endometrial cancer regardless of modality. VBT alone may be sufficient with stage II endometrial cancer regardless of grade or LVSI. Prospective data is required to further investigate and validate these results.Abstract TU_20_3520: Table 1Five-year Overall Survival (95% CI) of Stage II Endometrial Cancer by Grade and Radiation ModalityRadiation ModalityGradeVBTEBRTEBRT+VBT191.6% (87.0-94.7%)88.9% (82.2-93.2%)91.0% (86.2-94.2%)285.1% (80.4-88.7%)84.6% (79.0-88.8%)84.6% (80.7-87.8%)373.7% (67.0-79.3%)65.6% (58.5-71.8%)65.1% (59.0-70.5%) Open table in a new tab" @default.
• W2898049860 created "2018-10-26" @default.
• W2898049860 creator A5021903894 @default.
• W2898049860 creator A5038856704 @default.
• W2898049860 creator A5054512246 @default.
• W2898049860 creator A5061443122 @default.
• W2898049860 creator A5069486509 @default.
• W2898049860 creator A5073860897 @default.
• W2898049860 date "2018-11-01" @default.
• W2898049860 modified "2023-10-16" @default.
• W2898049860 title "Vaginal Brachytherapy and External Beam Radiation therapy in Operable Stage II Endometrial Cancer: A National Cancer Database Study" @default.
• W2898049860 doi "https://doi.org/10.1016/j.ijrobp.2018.07.1767" @default.
• W2898049860 hasPublicationYear "2018" @default.
• W2898049860 type Work @default.
• W2898049860 sameAs 2898049860 @default.
• W2898049860 citedByCount "0" @default.
• W2898049860 crossrefType "journal-article" @default.
• W2898049860 hasAuthorship W2898049860A5021903894 @default.
• W2898049860 hasAuthorship W2898049860A5038856704 @default.
• W2898049860 hasAuthorship W2898049860A5054512246 @default.
• W2898049860 hasAuthorship W2898049860A5061443122 @default.
• W2898049860 hasAuthorship W2898049860A5069486509 @default.
• W2898049860 hasAuthorship W2898049860A5073860897 @default.
• W2898049860 hasConcept C121608353 @default.
• W2898049860 hasConcept C126322002 @default.
• W2898049860 hasConcept C126894567 @default.
• W2898049860 hasConcept C141071460 @default.
• W2898049860 hasConcept C143998085 @default.
• W2898049860 hasConcept C146357865 @default.
• W2898049860 hasConcept C151730666 @default.
• W2898049860 hasConcept C2775908122 @default.
• W2898049860 hasConcept C2777088508 @default.
• W2898049860 hasConcept C2777416452 @default.
• W2898049860 hasConcept C2778220009 @default.
• W2898049860 hasConcept C2779494336 @default.
• W2898049860 hasConcept C509974204 @default.
• W2898049860 hasConcept C71924100 @default.
• W2898049860 hasConcept C86803240 @default.
• W2898049860 hasConceptScore W2898049860C121608353 @default.
• W2898049860 hasConceptScore W2898049860C126322002 @default.
• W2898049860 hasConceptScore W2898049860C126894567 @default.
• W2898049860 hasConceptScore W2898049860C141071460 @default.
• W2898049860 hasConceptScore W2898049860C143998085 @default.
• W2898049860 hasConceptScore W2898049860C146357865 @default.
• W2898049860 hasConceptScore W2898049860C151730666 @default.
• W2898049860 hasConceptScore W2898049860C2775908122 @default.
• W2898049860 hasConceptScore W2898049860C2777088508 @default.
• W2898049860 hasConceptScore W2898049860C2777416452 @default.
• W2898049860 hasConceptScore W2898049860C2778220009 @default.
• W2898049860 hasConceptScore W2898049860C2779494336 @default.
• W2898049860 hasConceptScore W2898049860C509974204 @default.
• W2898049860 hasConceptScore W2898049860C71924100 @default.
• W2898049860 hasConceptScore W2898049860C86803240 @default.
• W2898049860 hasIssue "3" @default.
• W2898049860 hasLocation W28980498601 @default.
• W2898049860 hasOpenAccess W2898049860 @default.
• W2898049860 hasPrimaryLocation W28980498601 @default.
• W2898049860 hasRelatedWork W2513916013 @default.
• W2898049860 hasRelatedWork W2942848944 @default.
• W2898049860 hasRelatedWork W2966036943 @default.
• W2898049860 hasRelatedWork W3029213237 @default.
• W2898049860 hasRelatedWork W3031343993 @default.
• W2898049860 hasRelatedWork W3104537559 @default.
• W2898049860 hasRelatedWork W4206581437 @default.
• W2898049860 hasRelatedWork W4237106564 @default.
• W2898049860 hasRelatedWork W4313546044 @default.
• W2898049860 hasRelatedWork W4364377845 @default.
• W2898049860 hasVolume "102" @default.
• W2898049860 isParatext "false" @default.
• W2898049860 isRetracted "false" @default.
• W2898049860 magId "2898049860" @default.
• W2898049860 workType "article" @default.