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- W2898050848 abstract "Physical activity may improve cognitive function or delay progression of Alzheimer's disease. There is insufficient evidence to justify the adoption of specific interventions to protect against cognitive decline. Reliable and quantitative longitudinal neuroimaging biomarkers for tracking of disease progression are paramount to inform therapeutic strategies. We explored microstructural imaging biomarkers in MCI adults who completed an exercise intervention using longitudinal diffusion tensor imaging (DTI). Longitudinal MR images for 34 adults with MCI were acquired as part of a randomized trial investigating the effects of aerobic exercise (n=15) versus stretching and balance (n=19) on brain health (PI: Baker). Images were acquired at baseline and 6 months later on a 3T scanner. High-resolution structural T1-weighted and diffusion-weighted images were collected, from which the longitudinal changes of DTI scalars (FA/MD/AD/RD) were estimated. All parameter maps were warped to population-based study-specific FA template space and voxel-wise statistical analysis was applied to examine intervention effects. Fiber tractography and crossing fiber modeling were performed in regions showing group differences to further examine FA change mechanisms in the relevant regions. Figure. Fiber tractography overlaid on FA template at left posterior thalamic ration (left panel) and right superior corona radiata (right panel). Consistent fiber orientation distribution was observed at PTR R (Purple cluster) while marked crossing fiber patterns were observed in SCR_R (Yellow cluster). Red, Green or Blue in fiber tractography represents orientation of fibers in Left-to-Right, Posterior-to-Anterior or Inferior-to-Superior, respectively. Methodological approaches that permit close examination of white matter fiber orientation in the analysis of FA may have important implications for data interpretation. Here, an apparent increase in FA for the control group was attributable to the presence of crossing fibers. With this resolve, the MR findings suggest a protective effect of aerobic exercise on microstructural integrity in MCI adults." @default.
- W2898050848 created "2018-10-26" @default.
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- W2898050848 date "2018-07-01" @default.
- W2898050848 modified "2023-10-16" @default.
- W2898050848 title "P3‐414: LONGITUDINAL ANALYSIS OF MICROSTRUCTURAL WHITE MATTER CHANGE IN MCI FOLLOWING A 6‐MONTH AEROBIC EXERCISE INTERVENTION" @default.
- W2898050848 doi "https://doi.org/10.1016/j.jalz.2018.06.1777" @default.
- W2898050848 hasPublicationYear "2018" @default.
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