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• W2898050913 abstract "Significance EGFR is a transmembrane cell-surface receptor tyrosine kinase crucial for regulating diverse physiological and pathological responses, but how protein function is turned on has remained elusive. Our results indicated that EGF stimulation recruits a key scaffold protein called TRAF4, which in turn recognizes the C-terminal half of the juxtamembrane segment of EGFR and promotes EGFR activation. Specific mutations in the TRAF4 binding site of EGFR resulted in significant attenuation of EGF-induced EGFR activation. These findings provide important insight into the mechanism of EGFR activation, and implicate TRAF4 as a potential therapeutic target for treating EGF/EGFR-driven cancers." @default.
• W2898050913 created "2018-10-26" @default.
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• W2898050913 date "2018-10-23" @default.
• W2898050913 modified "2023-10-13" @default.
• W2898050913 title "TRAF4 binds to the juxtamembrane region of EGFR directly and promotes kinase activation" @default.
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• W2898050913 doi "https://doi.org/10.1073/pnas.1809599115" @default.
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