FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898050935> ?p ?o ?g. }

• W2898050935 abstract "Rett syndrome (RTT) is a neurological disorder caused by the mutation of the X-linked MECP2 gene. Neurophysiological hallmark of RTT phenotype is the hyperexcitability of neurons that represent a cause of frequent epileptic attacks in the patients. This feature may stem from impaired glutamate handling in RTT but the concerning experimental data are yet lacking. We previously reported that the RTT hippocampal slices frequently show aberrant glutamate transients associated with repetitive burst firing in the CA1 neurons. We here examined the roles of ionotropic, and specifically, metabotropic glutamate receptors (GluR) in regulation of ambient glutamate handling and excitability in hippocampal organotypic slice from wild-type (WT) and Mecp2-/y mice (RTT). Stimulation of AMPA, kainate, NMDA and mGluR1/5 receptors in both WT and RTT slices induced a global release of glutamate measured with fluorescence sensor (iGluSnFr) expressed in CA1 neurons. The neuronal activity was transiently augmented and then depressed, respectively. After wash out of the agonists from WT slices, repetitive glutamate transients were established, whose pattern resembled that of naive RTT slices. In both neuronal types, the GluR agonists also induced delayed and long-lasting decrease in hyperpolarization-activated (HCN) and increase in voltage-sensitive calcium channel (VSCC) currents. The repetitive glutamate transients we reinforced by agonists to mGluR1/5 and their antagonists suppressed glutamate spikes. Postsynaptic modifications of activity were examined using a non-stationary noise analysis and back-propagating potentials (bAPs). After single application of glutamate agonists the single channel current and the number of postsynaptic calcium-permeable AMPARs increased. bAPs, which normally evoked afterdischarges lasted both in WT and RTT for ~2 min, were augmented by mGluR1/5 agonist. The effects were occluded by intracellular perfusion with AMPAR blocker and unchanged by NMDAR antagonist. We propose that glutamate release in RTT hippocampus stimulates extrasynaptic mGluR1/5 that modifies somatic and postsynaptic channels and make neurons hyperexcitable and more prone to spontaneous glutamate release." @default.
• W2898050935 created "2018-10-26" @default.
• W2898050935 creator A5007599409 @default.
• W2898050935 creator A5081166241 @default.
• W2898050935 date "2018-10-17" @default.
• W2898050935 modified "2023-10-16" @default.
• W2898050935 title "CA1 Neurons Acquire Rett Syndrome Phenotype After Brief Activation of Glutamatergic Receptors: Specific Role of mGluR1/5" @default.
• W2898050935 cites W1488982469 @default.
• W2898050935 cites W1537267296 @default.
• W2898050935 cites W1559125698 @default.
• W2898050935 cites W1574935607 @default.
• W2898050935 cites W1967133714 @default.
• W2898050935 cites W1970354504 @default.
• W2898050935 cites W1971930170 @default.
• W2898050935 cites W1972565753 @default.
• W2898050935 cites W1974916659 @default.
• W2898050935 cites W1975549839 @default.
• W2898050935 cites W1992965882 @default.
• W2898050935 cites W1994461349 @default.
• W2898050935 cites W1995933374 @default.
• W2898050935 cites W2007239691 @default.
• W2898050935 cites W2020383525 @default.
• W2898050935 cites W2046038256 @default.
• W2898050935 cites W2061942374 @default.
• W2898050935 cites W2071878782 @default.
• W2898050935 cites W2072233684 @default.
• W2898050935 cites W2076838768 @default.
• W2898050935 cites W2079054696 @default.
• W2898050935 cites W2080120821 @default.
• W2898050935 cites W2090938600 @default.
• W2898050935 cites W2092111445 @default.
• W2898050935 cites W2093174559 @default.
• W2898050935 cites W2095126933 @default.
• W2898050935 cites W2116447452 @default.
• W2898050935 cites W2125603023 @default.
• W2898050935 cites W2127311839 @default.
• W2898050935 cites W2128577307 @default.
• W2898050935 cites W2130127196 @default.
• W2898050935 cites W2147800368 @default.
• W2898050935 cites W2159190141 @default.
• W2898050935 cites W2259214560 @default.
• W2898050935 cites W2271928919 @default.
• W2898050935 cites W2303118532 @default.
• W2898050935 cites W2333165720 @default.
• W2898050935 cites W2550208751 @default.
• W2898050935 cites W2795704983 @default.
• W2898050935 cites W2892562286 @default.
• W2898050935 doi "https://doi.org/10.3389/fncel.2018.00363" @default.
• W2898050935 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6199391" @default.
• W2898050935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30386209" @default.
• W2898050935 hasPublicationYear "2018" @default.
• W2898050935 type Work @default.
• W2898050935 sameAs 2898050935 @default.
• W2898050935 citedByCount "8" @default.
• W2898050935 countsByYear W28980509352020 @default.
• W2898050935 countsByYear W28980509352021 @default.
• W2898050935 countsByYear W28980509352022 @default.
• W2898050935 crossrefType "journal-article" @default.
• W2898050935 hasAuthorship W2898050935A5007599409 @default.
• W2898050935 hasAuthorship W2898050935A5081166241 @default.
• W2898050935 hasBestOaLocation W28980509351 @default.
• W2898050935 hasConcept C115955781 @default.
• W2898050935 hasConcept C160268369 @default.
• W2898050935 hasConcept C169760540 @default.
• W2898050935 hasConcept C170493617 @default.
• W2898050935 hasConcept C185592680 @default.
• W2898050935 hasConcept C189184402 @default.
• W2898050935 hasConcept C197341189 @default.
• W2898050935 hasConcept C207951395 @default.
• W2898050935 hasConcept C2129178 @default.
• W2898050935 hasConcept C26702167 @default.
• W2898050935 hasConcept C2780648746 @default.
• W2898050935 hasConcept C2781001490 @default.
• W2898050935 hasConcept C41653306 @default.
• W2898050935 hasConcept C49051014 @default.
• W2898050935 hasConcept C55493867 @default.
• W2898050935 hasConcept C61174792 @default.
• W2898050935 hasConcept C73009533 @default.
• W2898050935 hasConcept C86803240 @default.
• W2898050935 hasConceptScore W2898050935C115955781 @default.
• W2898050935 hasConceptScore W2898050935C160268369 @default.
• W2898050935 hasConceptScore W2898050935C169760540 @default.
• W2898050935 hasConceptScore W2898050935C170493617 @default.
• W2898050935 hasConceptScore W2898050935C185592680 @default.
• W2898050935 hasConceptScore W2898050935C189184402 @default.
• W2898050935 hasConceptScore W2898050935C197341189 @default.
• W2898050935 hasConceptScore W2898050935C207951395 @default.
• W2898050935 hasConceptScore W2898050935C2129178 @default.
• W2898050935 hasConceptScore W2898050935C26702167 @default.
• W2898050935 hasConceptScore W2898050935C2780648746 @default.
• W2898050935 hasConceptScore W2898050935C2781001490 @default.
• W2898050935 hasConceptScore W2898050935C41653306 @default.
• W2898050935 hasConceptScore W2898050935C49051014 @default.
• W2898050935 hasConceptScore W2898050935C55493867 @default.
• W2898050935 hasConceptScore W2898050935C61174792 @default.
• W2898050935 hasConceptScore W2898050935C73009533 @default.
• W2898050935 hasConceptScore W2898050935C86803240 @default.
• W2898050935 hasFunder F4320320879 @default.
• W2898050935 hasLocation W28980509351 @default.
• W2898050935 hasLocation W28980509352 @default.

• next