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- W2898052380 abstract "Extracellular acidity is correlated with the development of various pathological states and bulk pH measurements could not report surface acidity. In this study, we have developed a ratiometric fluorescent probe that aggregates upon interaction with cells, allowing persistent labeling of cells and in situ measurement of cell surface pH. The ternary nanoplatform is constructed by a convenient noncovalent combination of bovine serum albumin protected gold nanoclusters (BSA-AuNCs), fluorescein isothiocyanate (FITC) labeled cationic peptides (CPs), and FITC-free CPs. The red fluorescent AuNCs serve as reference fluorophore, while FITC labeled peptides act as specific recognition element for H+ and FITC unlabeled peptides are used for delivery. The probe displays a sensitive fluorescence ratiometric response for pH in the range of 5.0–9.5 with calculated pKa of 7.2. Further studies have demonstrated that this nanosensor also has properties of high selectivity, reversibility to pH fluctuations, as well as low cytotoxicity. The new surface pH-measurement tool was validated in mapping extracellular pH and monitoring acidification regarding cell metabolism, demonstrating its potential for bioimaging and biosensing." @default.
- W2898052380 created "2018-10-26" @default.
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- W2898052380 date "2018-10-16" @default.
- W2898052380 modified "2023-10-16" @default.
- W2898052380 title "A Cell-Surface-Specific Ratiometric Fluorescent Probe for Extracellular pH Sensing with Solid-State Fluorophore" @default.
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- W2898052380 doi "https://doi.org/10.1021/acssensors.8b00514" @default.
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