FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898059209> ?p ?o ?g. }

• W2898059209 endingPage "698" @default.
• W2898059209 startingPage "698" @default.
• W2898059209 abstract "Hrd1 has recently emerged as a critical regulator of B-cells in autoimmune diseases. However, its role in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) remains largely unexplored. This study aimed to examine Hrd1 expression and B-cell accumulation and their possible roles in CRSwNP.Quantitative real-time polymerase chain reaction, immunohistochemistry, enzyme-linked immunosorbent assay and Western blotting were used to assess gene and protein expression in nasal tissue extracts. Cells isolated from nasal tissues and peripheral blood mononuclear cells were characterized by flow cytometry. Local antibody production was measured in tissue extracts with a Bio-Plex assay. Additionally, changes in Hrd1 expression in response to specific inflammatory stimuli were measured in cultured dispersed polyp cells.Nasal polyps (NPs) from patients with eosinophilic CRSwNP (ECRS) had increased levels of Hrd1, B-cells and plasma cells compared with NPs from patients with non-eosinophilic CRSwNP (non-ECRS) or other control subjects (P < 0.05). The average Hrd1 levels in B-cells in NPs from ECRS patients were significantly higher than those from non-ECRS patients and control subjects (P < 0.05). NPs also contained significantly increased levels of several antibody isotypes compared with normal controls (P < 0.05). Interestingly, Hrd1 expression in cultured polyp cells from ECRS patients, but not non-ECRS patients, was significantly increased by interleukin-1β, lipopolysaccharide and Poly(I:C) stimulation, and inhibited by dexamethasone treatment (P < 0.05).Differential Hrd1 expression and B-cell accumulation between the ECRS and non-ECRS subsets suggests that they can exhibit distinct pathogenic mechanisms and play important roles in NP." @default.
• W2898059209 created "2018-10-26" @default.
• W2898059209 creator A5017183277 @default.
• W2898059209 creator A5019831163 @default.
• W2898059209 creator A5022217280 @default.
• W2898059209 creator A5025543820 @default.
• W2898059209 creator A5027240571 @default.
• W2898059209 creator A5032971791 @default.
• W2898059209 creator A5048487323 @default.
• W2898059209 creator A5068561709 @default.
• W2898059209 creator A5083964242 @default.
• W2898059209 date "2018-01-01" @default.
• W2898059209 modified "2023-10-18" @default.
• W2898059209 title "Differential Hrd1 Expression and B-Cell Accumulation in Eosinophilic and Non-eosinophilic Chronic Rhinosinusitis With Nasal Polyps" @default.
• W2898059209 cites W1515845928 @default.
• W2898059209 cites W1885435857 @default.
• W2898059209 cites W1970891118 @default.
• W2898059209 cites W1972104377 @default.
• W2898059209 cites W1978596588 @default.
• W2898059209 cites W1988364921 @default.
• W2898059209 cites W2003355468 @default.
• W2898059209 cites W2003501014 @default.
• W2898059209 cites W2009501393 @default.
• W2898059209 cites W2010668367 @default.
• W2898059209 cites W2020996714 @default.
• W2898059209 cites W2030633414 @default.
• W2898059209 cites W2035887378 @default.
• W2898059209 cites W2039033334 @default.
• W2898059209 cites W2047977555 @default.
• W2898059209 cites W2053620243 @default.
• W2898059209 cites W2066006751 @default.
• W2898059209 cites W2073519389 @default.
• W2898059209 cites W2082526843 @default.
• W2898059209 cites W2086033558 @default.
• W2898059209 cites W2087380173 @default.
• W2898059209 cites W2097868610 @default.
• W2898059209 cites W2104268211 @default.
• W2898059209 cites W2115118609 @default.
• W2898059209 cites W2156959293 @default.
• W2898059209 cites W2164082063 @default.
• W2898059209 cites W2208093466 @default.
• W2898059209 cites W2467855616 @default.
• W2898059209 cites W2511184841 @default.
• W2898059209 cites W2560932310 @default.
• W2898059209 cites W2563901447 @default.
• W2898059209 cites W2567558689 @default.
• W2898059209 cites W2593651355 @default.
• W2898059209 cites W2766636923 @default.
• W2898059209 cites W3183099619 @default.
• W2898059209 doi "https://doi.org/10.4168/aair.2018.10.6.698" @default.
• W2898059209 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6182200" @default.
• W2898059209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30306751" @default.
• W2898059209 hasPublicationYear "2018" @default.
• W2898059209 type Work @default.
• W2898059209 sameAs 2898059209 @default.
• W2898059209 citedByCount "9" @default.
• W2898059209 countsByYear W28980592092020 @default.
• W2898059209 countsByYear W28980592092021 @default.
• W2898059209 countsByYear W28980592092022 @default.
• W2898059209 countsByYear W28980592092023 @default.
• W2898059209 crossrefType "journal-article" @default.
• W2898059209 hasAuthorship W2898059209A5017183277 @default.
• W2898059209 hasAuthorship W2898059209A5019831163 @default.
• W2898059209 hasAuthorship W2898059209A5022217280 @default.
• W2898059209 hasAuthorship W2898059209A5025543820 @default.
• W2898059209 hasAuthorship W2898059209A5027240571 @default.
• W2898059209 hasAuthorship W2898059209A5032971791 @default.
• W2898059209 hasAuthorship W2898059209A5048487323 @default.
• W2898059209 hasAuthorship W2898059209A5068561709 @default.
• W2898059209 hasAuthorship W2898059209A5083964242 @default.
• W2898059209 hasBestOaLocation W28980592092 @default.
• W2898059209 hasConcept C104317684 @default.
• W2898059209 hasConcept C137061746 @default.
• W2898059209 hasConcept C142724271 @default.
• W2898059209 hasConcept C153911025 @default.
• W2898059209 hasConcept C159654299 @default.
• W2898059209 hasConcept C202751555 @default.
• W2898059209 hasConcept C203014093 @default.
• W2898059209 hasConcept C204232928 @default.
• W2898059209 hasConcept C2776415932 @default.
• W2898059209 hasConcept C2777768476 @default.
• W2898059209 hasConcept C2779758542 @default.
• W2898059209 hasConcept C2780942790 @default.
• W2898059209 hasConcept C2781390199 @default.
• W2898059209 hasConcept C553184892 @default.
• W2898059209 hasConcept C55493867 @default.
• W2898059209 hasConcept C71924100 @default.
• W2898059209 hasConcept C86803240 @default.
• W2898059209 hasConceptScore W2898059209C104317684 @default.
• W2898059209 hasConceptScore W2898059209C137061746 @default.
• W2898059209 hasConceptScore W2898059209C142724271 @default.
• W2898059209 hasConceptScore W2898059209C153911025 @default.
• W2898059209 hasConceptScore W2898059209C159654299 @default.
• W2898059209 hasConceptScore W2898059209C202751555 @default.
• W2898059209 hasConceptScore W2898059209C203014093 @default.
• W2898059209 hasConceptScore W2898059209C204232928 @default.
• W2898059209 hasConceptScore W2898059209C2776415932 @default.
• W2898059209 hasConceptScore W2898059209C2777768476 @default.

• next