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• W2898063395 abstract "Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene cause CDKL5 Deficiency Disorder (CDD), a rare neurodevelopmental syndrome characterized by severe behavioural and physiological symptoms. No cure is available for CDD. CDKL5 is a kinase that is abundantly expressed in the brain and plays a critical role in neurodevelopmental processes, such as neuronal morphogenesis and plasticity. This study provides the first characterization of the neurobehavioural phenotype of 1 year old Cdkl5-null mice and demonstrates that stimulation of the serotonin receptor 7 (5-HT7R) with the agonist molecule LP-211 (0.25 mg/kg once/day for 7 days) partially rescues the abnormal phenotype and brain molecular alterations in Cdkl5-null male mice. In particular, LP-211 treatment completely normalizes the prepulse inhibition defects observed in Cdkl5-null mice and, at a molecular level, restores the abnormal cortical phosphorylation of rpS6, a downstream target of mTOR and S6 kinase, which plays a direct role in regulating protein synthesis. Moreover, we demonstrate for the first time that mitochondria show prominent functional abnormalities in Cdkl5-null mouse brains that can be restored by pharmacological stimulation of brain 5-HT7R." @default.
• W2898063395 created "2018-10-26" @default.
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• W2898063395 creator A5060819240 @default.
• W2898063395 date "2019-01-01" @default.
• W2898063395 modified "2023-10-11" @default.
• W2898063395 title "Rescue of prepulse inhibition deficit and brain mitochondrial dysfunction by pharmacological stimulation of the central serotonin receptor 7 in a mouse model of CDKL5 Deficiency Disorder" @default.
• W2898063395 cites W1254699444 @default.
• W2898063395 cites W1508450548 @default.
• W2898063395 cites W1580790875 @default.
• W2898063395 cites W1589880975 @default.
• W2898063395 cites W1963968145 @default.
• W2898063395 cites W1965336646 @default.
• W2898063395 cites W1966819687 @default.
• W2898063395 cites W1968577394 @default.
• W2898063395 cites W1968652252 @default.
• W2898063395 cites W1974482259 @default.
• W2898063395 cites W1975950121 @default.
• W2898063395 cites W1977206884 @default.
• W2898063395 cites W1978969846 @default.
• W2898063395 cites W1981225314 @default.
• W2898063395 cites W1981772054 @default.
• W2898063395 cites W1984305433 @default.
• W2898063395 cites W1984458059 @default.
• W2898063395 cites W1985254321 @default.
• W2898063395 cites W1989161195 @default.
• W2898063395 cites W1990862567 @default.
• W2898063395 cites W1998619221 @default.
• W2898063395 cites W1998662981 @default.
• W2898063395 cites W1999024554 @default.
• W2898063395 cites W1999775510 @default.
• W2898063395 cites W2005756201 @default.
• W2898063395 cites W2006423839 @default.
• W2898063395 cites W2013659972 @default.
• W2898063395 cites W2013927952 @default.
• W2898063395 cites W2017708470 @default.
• W2898063395 cites W2029950812 @default.
• W2898063395 cites W2034542541 @default.
• W2898063395 cites W2044316470 @default.
• W2898063395 cites W2049021349 @default.
• W2898063395 cites W2049868560 @default.
• W2898063395 cites W2057671833 @default.
• W2898063395 cites W2057993368 @default.
• W2898063395 cites W2059126452 @default.
• W2898063395 cites W2070559382 @default.
• W2898063395 cites W2076018693 @default.
• W2898063395 cites W2076825430 @default.
• W2898063395 cites W2080019131 @default.
• W2898063395 cites W2084522972 @default.
• W2898063395 cites W2086063461 @default.
• W2898063395 cites W2089421079 @default.
• W2898063395 cites W2090979638 @default.
• W2898063395 cites W2093930782 @default.
• W2898063395 cites W2100522604 @default.
• W2898063395 cites W2119383776 @default.
• W2898063395 cites W2125677514 @default.
• W2898063395 cites W2129032286 @default.
• W2898063395 cites W2129277563 @default.
• W2898063395 cites W2142319205 @default.
• W2898063395 cites W2143497500 @default.
• W2898063395 cites W2153200821 @default.
• W2898063395 cites W2153506277 @default.
• W2898063395 cites W2155848519 @default.
• W2898063395 cites W2157536563 @default.
• W2898063395 cites W2159923168 @default.
• W2898063395 cites W2175219089 @default.
• W2898063395 cites W2204086762 @default.
• W2898063395 cites W2214456560 @default.
• W2898063395 cites W2411805797 @default.
• W2898063395 cites W2468404860 @default.
• W2898063395 cites W2509522099 @default.
• W2898063395 cites W2582621819 @default.
• W2898063395 cites W2582734929 @default.
• W2898063395 cites W2606634315 @default.
• W2898063395 cites W2606730663 @default.
• W2898063395 cites W2707842729 @default.
• W2898063395 cites W2731200273 @default.
• W2898063395 cites W2734458034 @default.
• W2898063395 cites W2766209575 @default.
• W2898063395 cites W2767737184 @default.
• W2898063395 cites W2795144929 @default.
• W2898063395 cites W2800672823 @default.
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• W2898063395 doi "https://doi.org/10.1016/j.neuropharm.2018.10.018" @default.
• W2898063395 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30326240" @default.

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