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- W2898064401 abstract "Systematic review to evaluate local control and toxicities of perineal-based interstitial brachytherapy (P-ISBT) in primary vaginal cancers treated with three-dimensional (3D) image-based planning. Systematic review of the literature using the PRISMA guideline was conducted through a search of Medline, EMBASE and Cochrane databases. This search resulted in 20 relevant manuscripts plus one manuscript found outside of the search. Selected studies evaluated the role of P-ISBT in vaginal tumors treated using 3D planning. 6 of 21 manuscripts contained sufficient information for LC and toxicity calculations. Data were extracted by at least two investigators. A total of 252 vaginal cancer patients were treated with P-ISBT and planned with 3D image-based planning. Clinical outcomes could be identified for 112 patients and ranging from stage I to IVA and in majority of cases stage II-III. Most patients received 45–50.4 Gy EBRT to the pelvis followed by a P-ISBT boost with a range of median EQD2 between 23.8 and 33.8Gy, with majority of patients receiving 28-30 EQD2Gy. Total dose to patients were in a narrow range in median EQD2Gy (72.2 - 78.4). Patients were treated with either HDR, LDR, or PDR techniques, and a small number (2) received HDR plus PDR. Overall LC was 85% (95/112) with a median follow-up ranging from 17 to 45 months. Half of the patients (49%) had a median follow-up of at least 35 months. No significant procedure-related complications were reported. Combined late gastrointestinal, genitourinary and vaginal grade 3 and 4 toxicity was 11.6%. Promising LC rates were found in patients with vaginal cancers treated with perineal ISBT with 3D image-based planning. In this systematic review, tumors were most often stage II or III and yet a LC rate of 85% was found. P-ISBT with 3D planning seems to be an effective and safe treatment for primary vaginal tumors, though further investigation is required to optimize treatment given institutional variations in technique, planning and treatment protocol." @default.
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- W2898064401 date "2018-11-01" @default.
- W2898064401 modified "2023-09-24" @default.
- W2898064401 title "Three-Dimensional-Guided Perineal-Based Interstitial Brachytherapy in Primary Vaginal Cancer: A Systematic Review of Local Control and Toxicities" @default.
- W2898064401 doi "https://doi.org/10.1016/j.ijrobp.2018.07.1787" @default.
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