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- W2898064941 abstract "Microtubule-targeted agents (MTAs), widely used in chemotherapy, are molecules that are able to block cancer cell migration and division. Their effect on microtubule (MT) dynamic instability is measured by their influence on observable parameters of MT dynamics such as growth speed, time-based catastrophe frequency, time-based rescue fre- quency, etc. In this paper, we propose a new mathematical model that is able to reproduce MT dynamics with an appropriate estimation of the main observable parameters. Using the experimental data on paclitaxel effect in presence of EB proteins, we fitted param- eters of the model from several drug concentrations. It enable us to understand which non-observable model parameters are able to reproduce the effect of MTAs and thus to highlight a new potential mechanism of action associated with MTAs effect in presence of EB protein." @default.
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- W2898064941 date "2018-01-01" @default.
- W2898064941 modified "2023-10-17" @default.
- W2898064941 title "Mathematical Modeling of Effect Of Microtubule-Targeted Agents On Microtubule Dynamic Instability" @default.
- W2898064941 doi "https://doi.org/10.1051/proc/201862186201" @default.
- W2898064941 hasPublicationYear "2018" @default.
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