Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898068553> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2898068553 endingPage "214" @default.
- W2898068553 startingPage "210" @default.
- W2898068553 abstract "Bacteroides spp. are anaerobic resident intestinal flora but are also known to cause severe morbidity. They are resistant to a wide variety of antimicrobial agents, including metronidazole, which has been shown to be associated with specific nitroimidazole (nim) resistance genes. Metronidazole resistance is emerging worldwide, although presently it remains at ca. 5%. This study aimed to determine the metronidazole susceptibility and distribution of nim genes in Bacteroides spp. clinical isolates in India. The relationship among strains harbouring nim genes and their susceptibility to metronidazole was also analysed.A total of 42 Bacteroides spp. clinical isolates were identified using an advanced MALDI-TOF system. Minimum inhibitory concentrations (MICs) for metronidazole were determined by the agar dilution method. Bacterial DNA was extracted and was subjected to nim gene PCR and the amplified PCR products were sequenced to determine the prevalent nim types.Bacteroides fragilis was the most common isolate (64%) among all Bacteroides spp. isolates. Among the total 42 clinical Bacteroides spp. isolates, 29 (69%) were susceptible and 13 (31%) were resistant to metronidazole by the agar dilution method. nim gene PCR performed on 38 isolates showed positivity in 20 isolates (53%), of which 12 had high metronidazole MICs (χ2 test, P<0.005). On sequencing, these nim genes were most closely related to nimE type.Resistance to metronidazole is consistently emerging worldwide. There is a significant association of the nim gene with metronidazole resistance. Periodic surveillance is needed to detect geographic and temporal trends in nim gene prevalence." @default.
- W2898068553 created "2018-10-26" @default.
- W2898068553 creator A5008619627 @default.
- W2898068553 creator A5014628845 @default.
- W2898068553 creator A5021551803 @default.
- W2898068553 creator A5038077823 @default.
- W2898068553 creator A5064978017 @default.
- W2898068553 creator A5065915051 @default.
- W2898068553 date "2019-03-01" @default.
- W2898068553 modified "2023-10-01" @default.
- W2898068553 title "Emerging metronidazole resistance in Bacteroides spp. and its association with the nim gene: a study from North India" @default.
- W2898068553 cites W1987704238 @default.
- W2898068553 cites W1988170906 @default.
- W2898068553 cites W2035326642 @default.
- W2898068553 cites W2039627451 @default.
- W2898068553 cites W2056374619 @default.
- W2898068553 cites W2059124173 @default.
- W2898068553 cites W2106129585 @default.
- W2898068553 cites W2108709192 @default.
- W2898068553 cites W2111544673 @default.
- W2898068553 cites W2123005921 @default.
- W2898068553 cites W2136734723 @default.
- W2898068553 cites W2141903296 @default.
- W2898068553 cites W2146651683 @default.
- W2898068553 cites W2149797793 @default.
- W2898068553 cites W2168086802 @default.
- W2898068553 cites W2809502133 @default.
- W2898068553 cites W4251358894 @default.
- W2898068553 doi "https://doi.org/10.1016/j.jgar.2018.10.015" @default.
- W2898068553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30342928" @default.
- W2898068553 hasPublicationYear "2019" @default.
- W2898068553 type Work @default.
- W2898068553 sameAs 2898068553 @default.
- W2898068553 citedByCount "18" @default.
- W2898068553 countsByYear W28980685532021 @default.
- W2898068553 countsByYear W28980685532022 @default.
- W2898068553 countsByYear W28980685532023 @default.
- W2898068553 crossrefType "journal-article" @default.
- W2898068553 hasAuthorship W2898068553A5008619627 @default.
- W2898068553 hasAuthorship W2898068553A5014628845 @default.
- W2898068553 hasAuthorship W2898068553A5021551803 @default.
- W2898068553 hasAuthorship W2898068553A5038077823 @default.
- W2898068553 hasAuthorship W2898068553A5064978017 @default.
- W2898068553 hasAuthorship W2898068553A5065915051 @default.
- W2898068553 hasConcept C104317684 @default.
- W2898068553 hasConcept C176947019 @default.
- W2898068553 hasConcept C2777396551 @default.
- W2898068553 hasConcept C2778168646 @default.
- W2898068553 hasConcept C2780246119 @default.
- W2898068553 hasConcept C2780493024 @default.
- W2898068553 hasConcept C2909292399 @default.
- W2898068553 hasConcept C501593827 @default.
- W2898068553 hasConcept C523546767 @default.
- W2898068553 hasConcept C54355233 @default.
- W2898068553 hasConcept C86803240 @default.
- W2898068553 hasConcept C89423630 @default.
- W2898068553 hasConcept C94665300 @default.
- W2898068553 hasConceptScore W2898068553C104317684 @default.
- W2898068553 hasConceptScore W2898068553C176947019 @default.
- W2898068553 hasConceptScore W2898068553C2777396551 @default.
- W2898068553 hasConceptScore W2898068553C2778168646 @default.
- W2898068553 hasConceptScore W2898068553C2780246119 @default.
- W2898068553 hasConceptScore W2898068553C2780493024 @default.
- W2898068553 hasConceptScore W2898068553C2909292399 @default.
- W2898068553 hasConceptScore W2898068553C501593827 @default.
- W2898068553 hasConceptScore W2898068553C523546767 @default.
- W2898068553 hasConceptScore W2898068553C54355233 @default.
- W2898068553 hasConceptScore W2898068553C86803240 @default.
- W2898068553 hasConceptScore W2898068553C89423630 @default.
- W2898068553 hasConceptScore W2898068553C94665300 @default.
- W2898068553 hasLocation W28980685531 @default.
- W2898068553 hasLocation W28980685532 @default.
- W2898068553 hasOpenAccess W2898068553 @default.
- W2898068553 hasPrimaryLocation W28980685531 @default.
- W2898068553 hasRelatedWork W2061077605 @default.
- W2898068553 hasRelatedWork W2076576915 @default.
- W2898068553 hasRelatedWork W2084349905 @default.
- W2898068553 hasRelatedWork W2102488421 @default.
- W2898068553 hasRelatedWork W2128531432 @default.
- W2898068553 hasRelatedWork W2144211848 @default.
- W2898068553 hasRelatedWork W2416435423 @default.
- W2898068553 hasRelatedWork W2434375965 @default.
- W2898068553 hasRelatedWork W2898068553 @default.
- W2898068553 hasRelatedWork W3154687786 @default.
- W2898068553 hasVolume "16" @default.
- W2898068553 isParatext "false" @default.
- W2898068553 isRetracted "false" @default.
- W2898068553 magId "2898068553" @default.
- W2898068553 workType "article" @default.