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• W2898071340 abstract "4814 Inhibiting mutagenicity in experimental animals can provide an end point to evaluate the anti-mutagenic activity and safety of chemopreventive agents, and to predict their protective efficacy in humans. In this study, we studied the inhibitory ability of Methyl Sulfonyl Methane (MSM) on micronuclei (MN) formation of erythrocytes (ETCs) in bone marrow, induced by cyclophosphamide (CPA), a well-known anticancer drug that is mutagenic. MSM is a nutritional supplement used for pain relief. It is naturally found in food and in the human body. Our previous study has demonstrated that MSM possesses a cancer preventive activity in DMBA-induced mammary gland tumors of female SD rats. In this study, the inhibitory effect of MSM on MN formation induced by CPA was analyzed. Thirty 22-24g ICR mice were divided into 5 groups: control, 6.25, 12.5, 25, and 50 mg of CPA, 3 males and 3 females in each group. The control group was given 0.1ml/10 g body weight of saline by i.p. The other groups were given 6.25, 12.5, 25, and 50 mg/kg of CPA in saline by i.p. All animals were sacrificed by cervical dislocation at the 24th hour after CPA administration. The frequency of MN in bone marrow erythrocytes was determined under the light microscope (LM) at 1000X. The frequency of MN was 0.85 in the control group, 5.8, 9.4, 15.3, and 28.5 per 1000 ETC corresponding to the four doses of CPA respectively. The result indicated that 25 mg/kg CPA provided the optimum level of mutagenicity, which was chosen to be used for next experiment. Thirty 22-24 g ICR mice were divided into 5 groups: 2 untreated controls, and 3%, 5%, and 8% MSM groups. Each group contained 3 males and 3 females. MSM was supplied for 1 week in drinking water. On the 7th day, 25 mg/kg CPA was given by i.p. to all animals except the negative control group. All animals were sacrificed by cervical dislocation at the 24th hour after CPA administration. The frequency of MN was assessed under LM. MN in the negative control, positive CPA control, and 3%, 5%, and 8% MSM group were 0.85±1.03, 15.3±6.6, and 4.2±1.9, 4.6±1.5, and 2.3±1.5 per 1000 ETCs, respectively. The data indicated in an extremely significant manner that there was a 73%, 70%, and 85% inhibition of MN formation in the three doses of MSM compared to that of the positive controls. In conclusion, MSM is able to inhibit MN formation in bone marrow erythrocytes of ICR mice. Therefore, MSM may strongly protect the bone marrow from the toxicity of anticancer drugs and is safe for long-term preventive purposes. This data provides evidence, for the first time, of in vivo anti-mutagenicity of MSM on mammalian cells." @default.
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• W2898071340 date "2006-04-15" @default.
• W2898071340 modified "2023-10-03" @default.
• W2898071340 title "Anti-mutagenic activity of Methyl Sulfonyl Methane (MSM) in ICR mice" @default.
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