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- W2898072247 abstract "OBJECTIVES: We performed a prospective longitudinal study of the neuroanatomical and developmental changes in infants with transposition of the great arteries (TGA) or single ventricle (SV) physiology, to identify variables in anatomical development of the brain associated with functional impairment. We hypothesized that infants with TGA, whose oxygenation improved after early surgical correction, would have better neuroanatomical and developmental outcome than those with SV physiology who continued to have hypoxia. METHODS: Thirty-three infants with congenital heart defects, 23 with SV and 10 with TGA, were studied at around one year old (time 1) and three years old (time 2) by magnetic resonance imaging of the brain. Neurodevelomental assessment was performed at the same time. RESULTS: The whole and frontal lobe volumes were significantly reduced in both groups at time 1 compared with normal controls (P<0.01). However, by time 2 whole and frontal brain volumes were normal in the TGA group, but remained ..." @default.
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- W2898072247 date "2011-11-22" @default.
- W2898072247 modified "2023-09-22" @default.
- W2898072247 title "Abstract 12265: The Improvement of Hypoxia Correlates with Neuroanatomical and Developmental Outcomes in Infants with Transposition of the Great Arteries or Single Ventricle Physiology" @default.
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