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- W2898073648 abstract "Neuronal loss is a major pathological feature of Alzheimer's disease (AD). Nevertheless, the mechanisms underlying this key event in the disease pathogenesis are not clear. Necroptosis, a programmed form of necrosis, is performed by the mixed lineage kinase domain-like (MLKL) protein, which is activated by receptor-interactive protein kinases (RIPK) 1 and 3. Necroptosis is activated in various neurodegenerative disorders including multiple sclerosis and amyotrophic lateral sclerosis. However, it remains to be determined whether necroptosis plays a role in AD. We show that necroptosis is activated in human AD brains and its activation correlates with brain weight and cognitive scores. We also show that necroposis is also activated in 5xFAD mice, which are characterized by marked neuronal loss. Using complementary in vitro and in vivo approaches, we found that reducing necroptosis activation rescues AD-related neuronal loss. Overall, these data provide the first direct evidence that necroptosis is a mechanism involved in neurodegeneration in AD." @default.
- W2898073648 created "2018-10-26" @default.
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- W2898073648 date "2018-07-01" @default.
- W2898073648 modified "2023-10-16" @default.
- W2898073648 title "S3‐02‐01: NECROPTOSIS ACTIVATION IN ALZHEIMER'S DISEASE" @default.
- W2898073648 doi "https://doi.org/10.1016/j.jalz.2018.06.2735" @default.
- W2898073648 hasPublicationYear "2018" @default.
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