Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898075443> ?p ?o ?g. }
- W2898075443 endingPage "35" @default.
- W2898075443 startingPage "12" @default.
- W2898075443 abstract "Prior to 2002, hormone replacement therapy (HRT) was considered to be an important component of postmenopausal healthcare. This was based on a plethora of basic, epidemiological and clinical studies demonstrating the health benefits of supplementation with human sex steroids. However, adverse findings from the Women's Health Initiative (WHI) studies that examined the 2 major forms of HRT in use in the US at that time - Premarin (conjugated equine estrogens; CEE) and Prempro (CEE + medroxyprogesterone acetate; MPA), cast a shadow over the use of any form of HRT. Here we review the biochemical and physiological differences between the non-human WHI study hormones – CEE and MPA, and their respective human counterparts 17β-estradiol (E2) and progesterone (P4). Preclinical data from the last 30 years demonstrate clear differences between human and non-human sex steroids on numerous molecular, physiological and functional parameters in brain, heart and reproductive tissue. In contrast to CEE supplementation, which is not always detrimental although certainly not as optimal as E2 supplementation, MPA is clearly not equivalent to P4, having detrimental effects on cognitive, cardiac and reproductive function. Moreover, unlike P4, MPA is clearly antagonistic of the positive effects of E2 and CEE on tissue function. These data indicate that minor chemical changes to human sex steroids result in physiologically distinct actions that are not optimal for tissue health and functioning." @default.
- W2898075443 created "2018-10-26" @default.
- W2898075443 creator A5050300088 @default.
- W2898075443 creator A5067709976 @default.
- W2898075443 date "2019-01-01" @default.
- W2898075443 modified "2023-09-27" @default.
- W2898075443 title "Human versus non-human sex steroid use in hormone replacement therapies part 1: Preclinical data" @default.
- W2898075443 cites W1568189494 @default.
- W2898075443 cites W1574548440 @default.
- W2898075443 cites W1581090091 @default.
- W2898075443 cites W1586699954 @default.
- W2898075443 cites W1593442063 @default.
- W2898075443 cites W1593764750 @default.
- W2898075443 cites W160321674 @default.
- W2898075443 cites W1620990221 @default.
- W2898075443 cites W1861710919 @default.
- W2898075443 cites W1931351697 @default.
- W2898075443 cites W1932265632 @default.
- W2898075443 cites W1938529209 @default.
- W2898075443 cites W1943320567 @default.
- W2898075443 cites W1965585820 @default.
- W2898075443 cites W1966947659 @default.
- W2898075443 cites W1967472799 @default.
- W2898075443 cites W1967884605 @default.
- W2898075443 cites W1967963412 @default.
- W2898075443 cites W1968489938 @default.
- W2898075443 cites W1968728434 @default.
- W2898075443 cites W1969191990 @default.
- W2898075443 cites W1970761591 @default.
- W2898075443 cites W1971457115 @default.
- W2898075443 cites W1971867327 @default.
- W2898075443 cites W1971905646 @default.
- W2898075443 cites W1972341865 @default.
- W2898075443 cites W1972380077 @default.
- W2898075443 cites W1972471497 @default.
- W2898075443 cites W1973558156 @default.
- W2898075443 cites W1974355951 @default.
- W2898075443 cites W1976923556 @default.
- W2898075443 cites W1977217610 @default.
- W2898075443 cites W1977862283 @default.
- W2898075443 cites W1978543883 @default.
- W2898075443 cites W1978838839 @default.
- W2898075443 cites W1979770641 @default.
- W2898075443 cites W1980868004 @default.
- W2898075443 cites W1981141258 @default.
- W2898075443 cites W1981277980 @default.
- W2898075443 cites W1981841418 @default.
- W2898075443 cites W1981875905 @default.
- W2898075443 cites W1982594028 @default.
- W2898075443 cites W1983521550 @default.
- W2898075443 cites W1984333383 @default.
- W2898075443 cites W1985964755 @default.
- W2898075443 cites W1987324195 @default.
- W2898075443 cites W1988633109 @default.
- W2898075443 cites W1989242925 @default.
- W2898075443 cites W1989470448 @default.
- W2898075443 cites W1989954597 @default.
- W2898075443 cites W1990833831 @default.
- W2898075443 cites W1992301098 @default.
- W2898075443 cites W1993796132 @default.
- W2898075443 cites W1994129791 @default.
- W2898075443 cites W1996120399 @default.
- W2898075443 cites W1996422098 @default.
- W2898075443 cites W1996824135 @default.
- W2898075443 cites W1997996573 @default.
- W2898075443 cites W1998277030 @default.
- W2898075443 cites W2000243335 @default.
- W2898075443 cites W2000374562 @default.
- W2898075443 cites W2000450195 @default.
- W2898075443 cites W2000557258 @default.
- W2898075443 cites W2000673073 @default.
- W2898075443 cites W2001277388 @default.
- W2898075443 cites W2001943366 @default.
- W2898075443 cites W2002090514 @default.
- W2898075443 cites W2002297740 @default.
- W2898075443 cites W2003544058 @default.
- W2898075443 cites W2003864838 @default.
- W2898075443 cites W2004129996 @default.
- W2898075443 cites W2004584009 @default.
- W2898075443 cites W2006143195 @default.
- W2898075443 cites W2006377495 @default.
- W2898075443 cites W2006764433 @default.
- W2898075443 cites W2006851769 @default.
- W2898075443 cites W2008137415 @default.
- W2898075443 cites W2010206469 @default.
- W2898075443 cites W2010391061 @default.
- W2898075443 cites W2010560432 @default.
- W2898075443 cites W2012041763 @default.
- W2898075443 cites W2013347463 @default.
- W2898075443 cites W2013519213 @default.
- W2898075443 cites W2014389626 @default.
- W2898075443 cites W2015816296 @default.
- W2898075443 cites W2015830821 @default.
- W2898075443 cites W2016736193 @default.
- W2898075443 cites W2018215934 @default.
- W2898075443 cites W2021988869 @default.
- W2898075443 cites W2022587254 @default.
- W2898075443 cites W2023398724 @default.