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- W2898076487 abstract "Significance Enteric pathogens have to gauge the intestinal environment and adapt their metabolism and virulence strategies to establish themselves within the host. Here we show using a high-throughput screen that several metabolic pathways intertwine with virulence gene expression in enterohemorrhagic Escherichia coli . This screen identified transcriptional regulators that respond to fluctuations in amino and fatty acids as playing an important role in virulence gene expression both in vitro and during mammalian infection. Our study has fundamental implications for how differential gut metabolite compositions may affect disease outcome and susceptibility to pathogens." @default.
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- W2898076487 date "2018-10-22" @default.
- W2898076487 modified "2023-10-15" @default.
- W2898076487 title "Redox, amino acid, and fatty acid metabolism intersect with bacterial virulence in the gut" @default.
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- W2898076487 doi "https://doi.org/10.1073/pnas.1813451115" @default.
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