FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898077322> ?p ?o ?g. }

• W2898077322 endingPage "28S" @default.
• W2898077322 startingPage "8S" @default.
• W2898077322 abstract "Disseminated intravascular coagulation (DIC) is an acquired clinicobiological syndrome characterized by widespread activation of coagulation leading to fibrin deposition in the vasculature, organ dysfunction, consumption of clotting factors and platelets, and life-threatening hemorrhage. Disseminated intravascular coagulation is provoked by several underlying disorders (sepsis, cancer, trauma, and pregnancy complicated with eclampsia or other calamities). Treatment of the underlying disease and elimination of the trigger mechanism are the cornerstone therapeutic approaches. Therapeutic strategies specific for DIC aim to control activation of blood coagulation and bleeding risk. The clinical trials using DIC as entry criterion are limited. Large randomized, phase III clinical trials have investigated the efficacy of antithrombin (AT), activated protein C (APC), tissue factor pathway inhibitor (TFPI), and thrombomodulin (TM) in patients with sepsis, but the diagnosis of DIC was not part of the inclusion criteria. Treatment with APC reduced 28-day mortality of patients with severe sepsis, including patients retrospectively assigned to a subgroup with sepsis-associated DIC. Treatment with APC did not have any positive effects in other patient groups. The APC treatment increased the bleeding risk in patients with sepsis, which led to the withdrawal of this drug from the market. Treatment with AT failed to reduce 28-day mortality in patients with severe sepsis, but a retrospective subgroup analysis suggested possible efficacy in patients with DIC. Clinical studies with recombinant TFPI or TM have been carried out showing promising results. The efficacy and safety of other anticoagulants (ie, unfractionated heparin, low-molecular-weight heparin) or transfusion of platelet concentrates or clotting factor concentrates have not been objectively assessed." @default.
• W2898077322 created "2018-10-26" @default.
• W2898077322 creator A5007859032 @default.
• W2898077322 creator A5016255940 @default.
• W2898077322 creator A5043034719 @default.
• W2898077322 creator A5045621656 @default.
• W2898077322 creator A5059658717 @default.
• W2898077322 creator A5064983817 @default.
• W2898077322 creator A5076290258 @default.
• W2898077322 creator A5079392094 @default.
• W2898077322 creator A5091623390 @default.
• W2898077322 date "2018-10-08" @default.
• W2898077322 modified "2023-10-09" @default.
• W2898077322 title "Disseminated Intravascular Coagulation: An Update on Pathogenesis, Diagnosis, and Therapeutic Strategies" @default.
• W2898077322 cites W128594463 @default.
• W2898077322 cites W136849289 @default.
• W2898077322 cites W1525413164 @default.
• W2898077322 cites W1562986705 @default.
• W2898077322 cites W1566182873 @default.
• W2898077322 cites W1576352249 @default.
• W2898077322 cites W1577977383 @default.
• W2898077322 cites W1578821085 @default.
• W2898077322 cites W177064649 @default.
• W2898077322 cites W1880794324 @default.
• W2898077322 cites W1917222344 @default.
• W2898077322 cites W1929981269 @default.
• W2898077322 cites W1932895848 @default.
• W2898077322 cites W1954576125 @default.
• W2898077322 cites W1963602092 @default.
• W2898077322 cites W1967413818 @default.
• W2898077322 cites W1971938388 @default.
• W2898077322 cites W1980233581 @default.
• W2898077322 cites W1980425507 @default.
• W2898077322 cites W1986756094 @default.
• W2898077322 cites W1989317042 @default.
• W2898077322 cites W1989683484 @default.
• W2898077322 cites W1990040605 @default.
• W2898077322 cites W1991297902 @default.
• W2898077322 cites W1991307730 @default.
• W2898077322 cites W1993539946 @default.
• W2898077322 cites W1996911785 @default.
• W2898077322 cites W1997510499 @default.
• W2898077322 cites W2005018325 @default.
• W2898077322 cites W2005959990 @default.
• W2898077322 cites W2011993702 @default.
• W2898077322 cites W2017401577 @default.
• W2898077322 cites W2017699704 @default.
• W2898077322 cites W2017700181 @default.
• W2898077322 cites W2020513354 @default.
• W2898077322 cites W2021175298 @default.
• W2898077322 cites W2027093124 @default.
• W2898077322 cites W2029290028 @default.
• W2898077322 cites W2033165482 @default.
• W2898077322 cites W2034630400 @default.
• W2898077322 cites W2035196068 @default.
• W2898077322 cites W2036474812 @default.
• W2898077322 cites W2036920143 @default.
• W2898077322 cites W2037088990 @default.
• W2898077322 cites W2038396793 @default.
• W2898077322 cites W2043932193 @default.
• W2898077322 cites W2045321169 @default.
• W2898077322 cites W2047044508 @default.
• W2898077322 cites W2048425176 @default.
• W2898077322 cites W2051426690 @default.
• W2898077322 cites W2053002690 @default.
• W2898077322 cites W2053332000 @default.
• W2898077322 cites W2059243750 @default.
• W2898077322 cites W2059426768 @default.
• W2898077322 cites W2062154074 @default.
• W2898077322 cites W2071431452 @default.
• W2898077322 cites W2073688259 @default.
• W2898077322 cites W2074188685 @default.
• W2898077322 cites W2079211442 @default.
• W2898077322 cites W2082616171 @default.
• W2898077322 cites W2091462103 @default.
• W2898077322 cites W2091677130 @default.
• W2898077322 cites W2092976567 @default.
• W2898077322 cites W2096244180 @default.
• W2898077322 cites W2097841508 @default.
• W2898077322 cites W2100095744 @default.
• W2898077322 cites W2102243498 @default.
• W2898077322 cites W2104825124 @default.
• W2898077322 cites W2108435955 @default.
• W2898077322 cites W2111454506 @default.
• W2898077322 cites W2115301416 @default.
• W2898077322 cites W2119222862 @default.
• W2898077322 cites W2123409535 @default.
• W2898077322 cites W2127031087 @default.
• W2898077322 cites W2129921286 @default.
• W2898077322 cites W2134812248 @default.
• W2898077322 cites W2138035257 @default.
• W2898077322 cites W2144907217 @default.
• W2898077322 cites W2146504423 @default.
• W2898077322 cites W2154611259 @default.
• W2898077322 cites W2155154384 @default.
• W2898077322 cites W2155219561 @default.
• W2898077322 cites W2157199674 @default.
• W2898077322 cites W2159520495 @default.

• next