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- W2898080189 abstract "The complement system is a critical part of host defense to many bacterial, viral, and fungal infections. It works alongside pattern recognition receptors to stimulate host defense systems in advance of activation of the adaptive immune response. In this study, we directly test the role of complement in SARS-CoV pathogenesis using a mouse model and show that respiratory disease is significantly reduced in the absence of complement even though viral load is unchanged. Complement-deficient mice have reduced neutrophilia in their lungs and reduced systemic inflammation, consistent with the observation that SARS-CoV pathogenesis is an immune-driven disease. These data suggest that inhibition of complement signaling might be an effective treatment option following coronavirus infection." @default.
- W2898080189 created "2018-10-26" @default.
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- W2898080189 date "2018-11-07" @default.
- W2898080189 modified "2023-10-17" @default.
- W2898080189 title "Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis" @default.
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- W2898080189 doi "https://doi.org/10.1128/mbio.01753-18" @default.
- W2898080189 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6178621" @default.
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