Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898085019> ?p ?o ?g. }
- W2898085019 endingPage "202" @default.
- W2898085019 startingPage "194" @default.
- W2898085019 abstract "Abstract Background The time‐related decline in regenerative capacity and organ homeostasis is a major feature of aging. Rehmannia glutinosa and Astragalus membranaceus have been used as traditional Chinese herbal medicines for enhanced immunity and prolonged life. However, the mechanism by which this herbal medicine slows aging is unknown. In this study, we investigated the mechanism of the herbal anti‐aging effect. Methods Mice were fed diets supplemented with R. glutinosa or A. membranaceus for 10 months; the control group was fed a standard diet. The phenotypes were evaluated using a grading score system and survival analysis. The percentages of the senescence phenotypes of hematopoietic stem cells ( HSC s) were determined by fluorescence‐activated cell sorting analysis. The function and the mechanism of HSC s were analyzed by clonogenic assay and the real‐time polymerase chain reaction. Results The anti‐aging effect of R. glutinosa is due to the enhanced function of HSC s. Mice fed with R. glutinosa displayed characteristics of a slowed aging process, including decreased senescence and increased rate of survival. Flow cytometry analysis showed decreased numbers of Lin – Sca1 + c‐kit – ( LSK ) cells, long‐term HSC s ( LT ‐ HSC s) and short‐term HSC s ( ST ‐ HSC s) in the R. glutinosa group. In vitro, clonogenic assays showed increased self‐renewal ability of LT ‐ HSC s from the R. glutinosa group as well as maintaining LSK quiescence through upregulated p18 expression. The R. glutinosa group also showed decreased reactive oxygen species levels and the percentage of β‐gal + cells through downregulation of the cellular senescence‐associated protein p53 and p16. Conclusion Rehmannia glutinosa exerts anti‐aging effects by maintaining the quiescence and decreasing the senescence of HSC s." @default.
- W2898085019 created "2018-11-02" @default.
- W2898085019 creator A5002282925 @default.
- W2898085019 creator A5017541508 @default.
- W2898085019 creator A5078576975 @default.
- W2898085019 creator A5081088527 @default.
- W2898085019 creator A5085737881 @default.
- W2898085019 creator A5087664421 @default.
- W2898085019 date "2018-09-01" @default.
- W2898085019 modified "2023-10-16" @default.
- W2898085019 title "<i>Rehmannia glutinosa</i> exhibits anti-aging effect through maintaining the quiescence and decreasing the senescence of hematopoietic stem cells" @default.
- W2898085019 cites W1975462840 @default.
- W2898085019 cites W1985801522 @default.
- W2898085019 cites W1987195856 @default.
- W2898085019 cites W1987722299 @default.
- W2898085019 cites W1991891117 @default.
- W2898085019 cites W1996287334 @default.
- W2898085019 cites W2003360471 @default.
- W2898085019 cites W2008223253 @default.
- W2898085019 cites W2010345740 @default.
- W2898085019 cites W2012046106 @default.
- W2898085019 cites W2019266385 @default.
- W2898085019 cites W2032867856 @default.
- W2898085019 cites W2036055444 @default.
- W2898085019 cites W2045024858 @default.
- W2898085019 cites W2050637174 @default.
- W2898085019 cites W2058203200 @default.
- W2898085019 cites W2066630518 @default.
- W2898085019 cites W2066843562 @default.
- W2898085019 cites W2077264573 @default.
- W2898085019 cites W2080364970 @default.
- W2898085019 cites W2082301477 @default.
- W2898085019 cites W2087430697 @default.
- W2898085019 cites W2088038548 @default.
- W2898085019 cites W2094020798 @default.
- W2898085019 cites W2119704135 @default.
- W2898085019 cites W2126525177 @default.
- W2898085019 cites W2134924448 @default.
- W2898085019 cites W2149711855 @default.
- W2898085019 cites W2155485198 @default.
- W2898085019 cites W2802224583 @default.
- W2898085019 cites W2804587246 @default.
- W2898085019 cites W2811132457 @default.
- W2898085019 cites W2898085019 @default.
- W2898085019 doi "https://doi.org/10.1002/ame2.12034" @default.
- W2898085019 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6388079" @default.
- W2898085019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30891565" @default.
- W2898085019 hasPublicationYear "2018" @default.
- W2898085019 type Work @default.
- W2898085019 sameAs 2898085019 @default.
- W2898085019 citedByCount "18" @default.
- W2898085019 countsByYear W28980850192019 @default.
- W2898085019 countsByYear W28980850192020 @default.
- W2898085019 countsByYear W28980850192021 @default.
- W2898085019 countsByYear W28980850192022 @default.
- W2898085019 countsByYear W28980850192023 @default.
- W2898085019 crossrefType "journal-article" @default.
- W2898085019 hasAuthorship W2898085019A5002282925 @default.
- W2898085019 hasAuthorship W2898085019A5017541508 @default.
- W2898085019 hasAuthorship W2898085019A5078576975 @default.
- W2898085019 hasAuthorship W2898085019A5081088527 @default.
- W2898085019 hasAuthorship W2898085019A5085737881 @default.
- W2898085019 hasAuthorship W2898085019A5087664421 @default.
- W2898085019 hasBestOaLocation W28980850191 @default.
- W2898085019 hasConcept C104317684 @default.
- W2898085019 hasConcept C109159458 @default.
- W2898085019 hasConcept C117262875 @default.
- W2898085019 hasConcept C127561419 @default.
- W2898085019 hasConcept C142724271 @default.
- W2898085019 hasConcept C16685009 @default.
- W2898085019 hasConcept C188947578 @default.
- W2898085019 hasConcept C190283241 @default.
- W2898085019 hasConcept C203014093 @default.
- W2898085019 hasConcept C204787440 @default.
- W2898085019 hasConcept C2780100526 @default.
- W2898085019 hasConcept C2780798337 @default.
- W2898085019 hasConcept C28328180 @default.
- W2898085019 hasConcept C522857546 @default.
- W2898085019 hasConcept C553184892 @default.
- W2898085019 hasConcept C55493867 @default.
- W2898085019 hasConcept C71924100 @default.
- W2898085019 hasConcept C86803240 @default.
- W2898085019 hasConcept C95444343 @default.
- W2898085019 hasConceptScore W2898085019C104317684 @default.
- W2898085019 hasConceptScore W2898085019C109159458 @default.
- W2898085019 hasConceptScore W2898085019C117262875 @default.
- W2898085019 hasConceptScore W2898085019C127561419 @default.
- W2898085019 hasConceptScore W2898085019C142724271 @default.
- W2898085019 hasConceptScore W2898085019C16685009 @default.
- W2898085019 hasConceptScore W2898085019C188947578 @default.
- W2898085019 hasConceptScore W2898085019C190283241 @default.
- W2898085019 hasConceptScore W2898085019C203014093 @default.
- W2898085019 hasConceptScore W2898085019C204787440 @default.
- W2898085019 hasConceptScore W2898085019C2780100526 @default.
- W2898085019 hasConceptScore W2898085019C2780798337 @default.
- W2898085019 hasConceptScore W2898085019C28328180 @default.
- W2898085019 hasConceptScore W2898085019C522857546 @default.
- W2898085019 hasConceptScore W2898085019C553184892 @default.