FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898086063> ?p ?o ?g. }

• W2898086063 endingPage "5740" @default.
• W2898086063 startingPage "5728" @default.
• W2898086063 abstract "Anticancer drugs cannot be located in the tumor efficiently when intravenously administered because of their weak tissue specificity and often present the problems of low therapeutic activity and severe adverse effects. To conquer these challenges, a targeting nanomedicine system based on human body cells or cell derivates have drawn more attention from scientists in recent decades. In this work, we used doxorubicin (DOX) as a model drug and a nanoerythrocyte modified with folic acid (FA) and polyethylene glycol (PEG) as a carrier to develop a novel tumor targeting drug delivery system (FA/PEG–DOX–Nano-RBCs) to enhance antitumor efficacy and reduce drug-related toxicity. The results showed that this drug delivery system exhibited inspiring features including nanoscale particle size with uniform distribution, good physicochemical stability, and sustained drug release behavior. Compared with DOX injection, FA/PEG–DOX–Nano-RBCs can greatly prolong the drug circulation time in vivo and upgrade the drug concentration accumulated in tumor tissue. Moreover, FA/PEG–DOX–Nano-RBCs exerted stronger antitumor efficacy in vivo against liver cancer and showed superior safety. In conclusion, a surface-modified nanoerythrocyte was a promising drug delivery vehicle for achieving improved therapeutic efficacy and reduced systemic adverse effects for anticancer drugs." @default.
• W2898086063 created "2018-11-02" @default.
• W2898086063 creator A5004307620 @default.
• W2898086063 creator A5012529259 @default.
• W2898086063 creator A5016001046 @default.
• W2898086063 creator A5050940474 @default.
• W2898086063 creator A5064683226 @default.
• W2898086063 date "2018-10-25" @default.
• W2898086063 modified "2023-09-25" @default.
• W2898086063 title "Surface-Modified Nanoerythrocyte Loading DOX for Targeted Liver Cancer Chemotherapy" @default.
• W2898086063 cites W1156966783 @default.
• W2898086063 cites W1778816764 @default.
• W2898086063 cites W1968766681 @default.
• W2898086063 cites W1976915466 @default.
• W2898086063 cites W1985149245 @default.
• W2898086063 cites W1996665052 @default.
• W2898086063 cites W2000205238 @default.
• W2898086063 cites W2004484945 @default.
• W2898086063 cites W2006885736 @default.
• W2898086063 cites W2033465961 @default.
• W2898086063 cites W2039292971 @default.
• W2898086063 cites W2043142128 @default.
• W2898086063 cites W2052698492 @default.
• W2898086063 cites W2052727603 @default.
• W2898086063 cites W2054911358 @default.
• W2898086063 cites W2056842005 @default.
• W2898086063 cites W2074385248 @default.
• W2898086063 cites W2074939270 @default.
• W2898086063 cites W2076245386 @default.
• W2898086063 cites W2078147660 @default.
• W2898086063 cites W2079518017 @default.
• W2898086063 cites W2080926921 @default.
• W2898086063 cites W2094399039 @default.
• W2898086063 cites W2099228074 @default.
• W2898086063 cites W2099992138 @default.
• W2898086063 cites W2119376416 @default.
• W2898086063 cites W2126042413 @default.
• W2898086063 cites W2127785900 @default.
• W2898086063 cites W2140182328 @default.
• W2898086063 cites W2141777108 @default.
• W2898086063 cites W2157963288 @default.
• W2898086063 cites W2173044124 @default.
• W2898086063 cites W2293176103 @default.
• W2898086063 cites W2333629601 @default.
• W2898086063 cites W2340222014 @default.
• W2898086063 cites W2443004012 @default.
• W2898086063 cites W2521919010 @default.
• W2898086063 cites W2541936781 @default.
• W2898086063 cites W2563186034 @default.
• W2898086063 cites W2564776132 @default.
• W2898086063 cites W2582585325 @default.
• W2898086063 cites W2597228335 @default.
• W2898086063 cites W2598243100 @default.
• W2898086063 cites W2761920910 @default.
• W2898086063 cites W2783495750 @default.
• W2898086063 cites W2792475592 @default.
• W2898086063 cites W2795573780 @default.
• W2898086063 cites W2802674276 @default.
• W2898086063 cites W2850086439 @default.
• W2898086063 cites W2887659556 @default.
• W2898086063 cites W4242509007 @default.
• W2898086063 doi "https://doi.org/10.1021/acs.molpharmaceut.8b00881" @default.
• W2898086063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30359027" @default.
• W2898086063 hasPublicationYear "2018" @default.
• W2898086063 type Work @default.
• W2898086063 sameAs 2898086063 @default.
• W2898086063 citedByCount "31" @default.
• W2898086063 countsByYear W28980860632019 @default.
• W2898086063 countsByYear W28980860632020 @default.
• W2898086063 countsByYear W28980860632021 @default.
• W2898086063 countsByYear W28980860632022 @default.
• W2898086063 countsByYear W28980860632023 @default.
• W2898086063 crossrefType "journal-article" @default.
• W2898086063 hasAuthorship W2898086063A5004307620 @default.
• W2898086063 hasAuthorship W2898086063A5012529259 @default.
• W2898086063 hasAuthorship W2898086063A5016001046 @default.
• W2898086063 hasAuthorship W2898086063A5050940474 @default.
• W2898086063 hasAuthorship W2898086063A5064683226 @default.
• W2898086063 hasConcept C10138342 @default.
• W2898086063 hasConcept C110121322 @default.
• W2898086063 hasConcept C112705442 @default.
• W2898086063 hasConcept C121608353 @default.
• W2898086063 hasConcept C126322002 @default.
• W2898086063 hasConcept C126511603 @default.
• W2898086063 hasConcept C134306372 @default.
• W2898086063 hasConcept C15083742 @default.
• W2898086063 hasConcept C150903083 @default.
• W2898086063 hasConcept C155672457 @default.
• W2898086063 hasConcept C162324750 @default.
• W2898086063 hasConcept C171250308 @default.
• W2898086063 hasConcept C178790620 @default.
• W2898086063 hasConcept C185592680 @default.
• W2898086063 hasConcept C192562407 @default.
• W2898086063 hasConcept C207001950 @default.
• W2898086063 hasConcept C2776231280 @default.
• W2898086063 hasConcept C2776694085 @default.
• W2898086063 hasConcept C2779820397 @default.
• W2898086063 hasConcept C2780035454 @default.

• next