Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898086106> ?p ?o ?g. }
- W2898086106 endingPage "856" @default.
- W2898086106 startingPage "848" @default.
- W2898086106 abstract "p38 mitogen-activated protein kinase (MAPK) is an important protein which plays a key role in regulating the innate immunity, so exploring its molecular characterization is helpful in understanding the resistance against microbial infections in cultured fish. Here, a full-length cDNA of p38 MAPK was cloned from liver of blunt snout bream (Megalobrama amblycephala) which covered 2419 bp with an open reading frame of 1086 bp encoding 361 amino acids. p38 MAPK contained the characteristic structures of Thr-Gly-Tyr (TGY) motif and substrate binding site Ala-Thr-Arg-Trp (ATRW), which are conserved in MAPK family. To investigate p38 MAPK functions, two in vivo experiments were carried out to examine its expression following ammonia exposure and bacterial challenge. Also, an in vitro experiment was conducted to assess the role of p38 MAPK in inflammation of primary hepatocytes induced by lipopolysaccharide (LPS). The results showed the ubiquitous expression of p38 MAPK in all the tested tissues with varying levels. p38 MAPK mRNA expression was significantly up-regulated by ammonia stress and Aeromonas hydrophila challenge, and altered in a time-dependent manner. Moreover, the results indicated that the inflammatory response induced by LPS in hepatocytes is p38 MAPK dependent as knockdown of p38 MAPK using siRNA technology depressed the expression of IL-1β and IL-6. The findings in this study showed that p38 MAPK has anti-stress property, and plays key role in protection against bacterial infection and inflammation in blunt snout bream." @default.
- W2898086106 created "2018-11-02" @default.
- W2898086106 creator A5002069612 @default.
- W2898086106 creator A5003807314 @default.
- W2898086106 creator A5006313284 @default.
- W2898086106 creator A5011952320 @default.
- W2898086106 creator A5012620274 @default.
- W2898086106 date "2019-01-01" @default.
- W2898086106 modified "2023-10-10" @default.
- W2898086106 title "Molecular characterization of p38 MAPK from blunt snout bream (Megalobrama amblycephala) and its expression after ammonia stress, and lipopolysaccharide and bacterial challenge" @default.
- W2898086106 cites W1412752787 @default.
- W2898086106 cites W1966103571 @default.
- W2898086106 cites W1968504719 @default.
- W2898086106 cites W1972946410 @default.
- W2898086106 cites W1977698433 @default.
- W2898086106 cites W1978572651 @default.
- W2898086106 cites W1984022610 @default.
- W2898086106 cites W1989402989 @default.
- W2898086106 cites W1997696708 @default.
- W2898086106 cites W2007805771 @default.
- W2898086106 cites W2007986629 @default.
- W2898086106 cites W2010297202 @default.
- W2898086106 cites W2011114944 @default.
- W2898086106 cites W2032035225 @default.
- W2898086106 cites W2034184306 @default.
- W2898086106 cites W2035100406 @default.
- W2898086106 cites W2039201738 @default.
- W2898086106 cites W2042336339 @default.
- W2898086106 cites W2053383702 @default.
- W2898086106 cites W2054116154 @default.
- W2898086106 cites W2061113380 @default.
- W2898086106 cites W2061451047 @default.
- W2898086106 cites W2064943475 @default.
- W2898086106 cites W2066215328 @default.
- W2898086106 cites W2071153998 @default.
- W2898086106 cites W2075683397 @default.
- W2898086106 cites W2082754396 @default.
- W2898086106 cites W2087665354 @default.
- W2898086106 cites W2106882534 @default.
- W2898086106 cites W2108674671 @default.
- W2898086106 cites W2114463884 @default.
- W2898086106 cites W2122049215 @default.
- W2898086106 cites W2125121305 @default.
- W2898086106 cites W2129731952 @default.
- W2898086106 cites W2134692718 @default.
- W2898086106 cites W2140184966 @default.
- W2898086106 cites W2140369038 @default.
- W2898086106 cites W2145796537 @default.
- W2898086106 cites W2150386610 @default.
- W2898086106 cites W2162827783 @default.
- W2898086106 cites W2299210580 @default.
- W2898086106 cites W2300512546 @default.
- W2898086106 cites W2548655448 @default.
- W2898086106 cites W2569833764 @default.
- W2898086106 cites W2590229152 @default.
- W2898086106 cites W2883692566 @default.
- W2898086106 cites W4233853772 @default.
- W2898086106 cites W4288012 @default.
- W2898086106 doi "https://doi.org/10.1016/j.fsi.2018.10.074" @default.
- W2898086106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30381267" @default.
- W2898086106 hasPublicationYear "2019" @default.
- W2898086106 type Work @default.
- W2898086106 sameAs 2898086106 @default.
- W2898086106 citedByCount "10" @default.
- W2898086106 countsByYear W28980861062020 @default.
- W2898086106 countsByYear W28980861062021 @default.
- W2898086106 countsByYear W28980861062022 @default.
- W2898086106 countsByYear W28980861062023 @default.
- W2898086106 crossrefType "journal-article" @default.
- W2898086106 hasAuthorship W2898086106A5002069612 @default.
- W2898086106 hasAuthorship W2898086106A5003807314 @default.
- W2898086106 hasAuthorship W2898086106A5006313284 @default.
- W2898086106 hasAuthorship W2898086106A5011952320 @default.
- W2898086106 hasAuthorship W2898086106A5012620274 @default.
- W2898086106 hasConcept C104317684 @default.
- W2898086106 hasConcept C153911025 @default.
- W2898086106 hasConcept C173396325 @default.
- W2898086106 hasConcept C184235292 @default.
- W2898086106 hasConcept C190283241 @default.
- W2898086106 hasConcept C203014093 @default.
- W2898086106 hasConcept C2778130612 @default.
- W2898086106 hasConcept C2778754761 @default.
- W2898086106 hasConcept C51551487 @default.
- W2898086106 hasConcept C55493867 @default.
- W2898086106 hasConcept C57074206 @default.
- W2898086106 hasConcept C86803240 @default.
- W2898086106 hasConcept C95444343 @default.
- W2898086106 hasConceptScore W2898086106C104317684 @default.
- W2898086106 hasConceptScore W2898086106C153911025 @default.
- W2898086106 hasConceptScore W2898086106C173396325 @default.
- W2898086106 hasConceptScore W2898086106C184235292 @default.
- W2898086106 hasConceptScore W2898086106C190283241 @default.
- W2898086106 hasConceptScore W2898086106C203014093 @default.
- W2898086106 hasConceptScore W2898086106C2778130612 @default.
- W2898086106 hasConceptScore W2898086106C2778754761 @default.
- W2898086106 hasConceptScore W2898086106C51551487 @default.
- W2898086106 hasConceptScore W2898086106C55493867 @default.
- W2898086106 hasConceptScore W2898086106C57074206 @default.