FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898089571> ?p ?o ?g. }

• W2898089571 endingPage "14057" @default.
• W2898089571 startingPage "14046" @default.
• W2898089571 abstract "Albeit many studies demonstrated that the accumulation of phospholipids in the intestinal mucosal surfaces is essential for the protection of colon epithelia against pathogenic bacteria, the mechanism of interactions between phospholipids and the surface protein mucin is not well understood. In this study, the significance of interfacial interactions between phospholipids and mucin proteins was quantified by the combination of an in vitro intestinal surface model and label-free microinterferometry. The model of intestinal surfaces consists of planar lipid membranes deposited on solid substrates (supported membranes) that display mucin proteins at defined surface densities. Following the quantitative characterization of the systems, we monitored the vertical fluctuation of 10 μm-large particles on model intestinal surfaces by using microinterferometry, and calculated the effective interfacial interaction potentials by analytically solving the Langevin equation. We found that the spring constant of interfacial potentials calculated based on a harmonic approximation increased concomitantly with the increase in surface potentials, indicating the dominant role of electrostatic interactions. Intriguingly, the spring constants of particles coated with phospholipids do not follow electrostatic interactions. The spring constant of particles coated with zwitterionic phosphatidylcholine was larger compared to membranes incorporating positively or negatively charged lipids. Our data suggested the presence of another underlying molecular level interaction, such as phosphocholine–saccharide interactions. The fact that phosphatidylcholine sustains the binding capability to enzymatically degraded mucin suggests that the direct delivery of phosphatidylcholine to the damaged mucus is a promising strategy for the better treatment of patients affected by inflammatory bowel diseases." @default.
• W2898089571 created "2018-11-02" @default.
• W2898089571 creator A5050590376 @default.
• W2898089571 creator A5062695234 @default.
• W2898089571 creator A5069964740 @default.
• W2898089571 creator A5072719414 @default.
• W2898089571 date "2018-10-25" @default.
• W2898089571 modified "2023-10-17" @default.
• W2898089571 title "Nonclassical Interactions of Phosphatidylcholine with Mucin Protect Intestinal Surfaces: A Microinterferometry Study" @default.
• W2898089571 cites W1145617597 @default.
• W2898089571 cites W1775439135 @default.
• W2898089571 cites W1964128383 @default.
• W2898089571 cites W1964491166 @default.
• W2898089571 cites W1965127919 @default.
• W2898089571 cites W1966089227 @default.
• W2898089571 cites W1969507309 @default.
• W2898089571 cites W1975117221 @default.
• W2898089571 cites W1978739111 @default.
• W2898089571 cites W1982043987 @default.
• W2898089571 cites W1986187981 @default.
• W2898089571 cites W1986828225 @default.
• W2898089571 cites W1987102926 @default.
• W2898089571 cites W1988774285 @default.
• W2898089571 cites W1994984343 @default.
• W2898089571 cites W2023022008 @default.
• W2898089571 cites W2030590304 @default.
• W2898089571 cites W2032476367 @default.
• W2898089571 cites W2037066033 @default.
• W2898089571 cites W2041585049 @default.
• W2898089571 cites W2041711980 @default.
• W2898089571 cites W2044853699 @default.
• W2898089571 cites W2047668535 @default.
• W2898089571 cites W2050817202 @default.
• W2898089571 cites W2053625634 @default.
• W2898089571 cites W2054513967 @default.
• W2898089571 cites W2063233815 @default.
• W2898089571 cites W2066238318 @default.
• W2898089571 cites W2066690546 @default.
• W2898089571 cites W2082732215 @default.
• W2898089571 cites W2083102356 @default.
• W2898089571 cites W2084905196 @default.
• W2898089571 cites W2088373939 @default.
• W2898089571 cites W2094428443 @default.
• W2898089571 cites W2099524992 @default.
• W2898089571 cites W2110084817 @default.
• W2898089571 cites W2110474020 @default.
• W2898089571 cites W2113403170 @default.
• W2898089571 cites W2125858990 @default.
• W2898089571 cites W2127690112 @default.
• W2898089571 cites W2138914111 @default.
• W2898089571 cites W2142432823 @default.
• W2898089571 cites W2159969340 @default.
• W2898089571 cites W2163366447 @default.
• W2898089571 cites W2171029753 @default.
• W2898089571 cites W2328064770 @default.
• W2898089571 cites W2342250425 @default.
• W2898089571 cites W2471715767 @default.
• W2898089571 cites W2587766667 @default.
• W2898089571 cites W2733829642 @default.
• W2898089571 cites W2792981919 @default.
• W2898089571 cites W2888081643 @default.
• W2898089571 cites W3092143728 @default.
• W2898089571 cites W3101508961 @default.
• W2898089571 cites W4230372669 @default.
• W2898089571 cites W4238055092 @default.
• W2898089571 doi "https://doi.org/10.1021/acs.langmuir.8b03035" @default.
• W2898089571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30359036" @default.
• W2898089571 hasPublicationYear "2018" @default.
• W2898089571 type Work @default.
• W2898089571 sameAs 2898089571 @default.
• W2898089571 citedByCount "6" @default.
• W2898089571 countsByYear W28980895712019 @default.
• W2898089571 countsByYear W28980895712021 @default.
• W2898089571 countsByYear W28980895712022 @default.
• W2898089571 countsByYear W28980895712023 @default.
• W2898089571 crossrefType "journal-article" @default.
• W2898089571 hasAuthorship W2898089571A5050590376 @default.
• W2898089571 hasAuthorship W2898089571A5062695234 @default.
• W2898089571 hasAuthorship W2898089571A5069964740 @default.
• W2898089571 hasAuthorship W2898089571A5072719414 @default.
• W2898089571 hasConcept C117626034 @default.
• W2898089571 hasConcept C121332964 @default.
• W2898089571 hasConcept C12554922 @default.
• W2898089571 hasConcept C127413603 @default.
• W2898089571 hasConcept C147789679 @default.
• W2898089571 hasConcept C159467904 @default.
• W2898089571 hasConcept C179264091 @default.
• W2898089571 hasConcept C185592680 @default.
• W2898089571 hasConcept C18903297 @default.
• W2898089571 hasConcept C2776330855 @default.
• W2898089571 hasConcept C2777312293 @default.
• W2898089571 hasConcept C2778918659 @default.
• W2898089571 hasConcept C41625074 @default.
• W2898089571 hasConcept C42360764 @default.
• W2898089571 hasConcept C55493867 @default.
• W2898089571 hasConcept C62520636 @default.
• W2898089571 hasConcept C86803240 @default.
• W2898089571 hasConcept C87716614 @default.

• next