FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898090286> ?p ?o ?g. }

• W2898090286 endingPage "e0206093" @default.
• W2898090286 startingPage "e0206093" @default.
• W2898090286 abstract "Zika virus (ZIKV) is an emerging arbovirus of the Flaviviridae family. Although infection with ZIKV generally leads to mild disease, its recent emergence in the Americas has been associated with an increase in the development of the Guillain-Barré syndrome in adults, as well as with neurological complications, in particular congenital microcephaly, in new-borns. To date, little information is available on neuroinflammation induced by ZIKV, notably in microglial cells in the context of their metabolic activity, a series of chemical transformations that are essential for their growth, reproduction, structural maintenance and environmental responses. Therefore, in the present study we investigated the metabolomic profile of ZIKV-infected microglia. Microglial cells were exposed to ZIKV at different time points and were analyzed by a Liquid Chromatography-High Resolution mass spectrometry-based metabolomic approach. The results show that ZIKV infection in microglia leads to modulation of the expression of numerous metabolites, including lysophospholipids, particulary Lysophosphatidylcholine, and phospholipids such as Phosphatidylcholine, Phosphatidylserine, Ceramide and Sphingomyelin, and carboxylicic acids as Undecanedioic and Dodecanedioic acid. Some of these metabolites are involved in neuronal differentiation, regulation of apoptosis, virion architecture and viral replication. ZIKV infection was associated with concomitant secretion of inflammatory mediators linked with central nervous system inflammation such as IL-6, TNF-α, IL-1β, iNOS and NO. It also resulted in the upregulation of the expression of the gene encoding CX3CR1, a chemokine receptor known to regulate functional synapse plasticity and signaling between microglial cells. These findings highlight an important role for microglia and their metabolites in the process of neuroinflammation that occurs during ZIKV pathogenesis." @default.
• W2898090286 created "2018-11-02" @default.
• W2898090286 creator A5007864114 @default.
• W2898090286 creator A5027202045 @default.
• W2898090286 creator A5034769845 @default.
• W2898090286 creator A5036491309 @default.
• W2898090286 creator A5050716556 @default.
• W2898090286 creator A5053677600 @default.
• W2898090286 creator A5056075180 @default.
• W2898090286 creator A5063028605 @default.
• W2898090286 creator A5068395602 @default.
• W2898090286 creator A5076663213 @default.
• W2898090286 creator A5087872155 @default.
• W2898090286 creator A5090272472 @default.
• W2898090286 date "2018-10-25" @default.
• W2898090286 modified "2023-10-18" @default.
• W2898090286 title "Zika virus infection modulates the metabolomic profile of microglial cells" @default.
• W2898090286 cites W1541898632 @default.
• W2898090286 cites W1543068333 @default.
• W2898090286 cites W1545235721 @default.
• W2898090286 cites W1560207168 @default.
• W2898090286 cites W1805149125 @default.
• W2898090286 cites W1857453373 @default.
• W2898090286 cites W1931440368 @default.
• W2898090286 cites W1965270224 @default.
• W2898090286 cites W1975120587 @default.
• W2898090286 cites W1994472770 @default.
• W2898090286 cites W2002251052 @default.
• W2898090286 cites W2017870786 @default.
• W2898090286 cites W2018686878 @default.
• W2898090286 cites W2032564702 @default.
• W2898090286 cites W2037943448 @default.
• W2898090286 cites W2045798092 @default.
• W2898090286 cites W2065210647 @default.
• W2898090286 cites W2071620927 @default.
• W2898090286 cites W2085335543 @default.
• W2898090286 cites W2088542086 @default.
• W2898090286 cites W2095777272 @default.
• W2898090286 cites W2097491647 @default.
• W2898090286 cites W2111425451 @default.
• W2898090286 cites W2122349387 @default.
• W2898090286 cites W2132482183 @default.
• W2898090286 cites W2139961441 @default.
• W2898090286 cites W2147531177 @default.
• W2898090286 cites W2151603054 @default.
• W2898090286 cites W2158745183 @default.
• W2898090286 cites W2185151415 @default.
• W2898090286 cites W2224061626 @default.
• W2898090286 cites W2263746595 @default.
• W2898090286 cites W2281227512 @default.
• W2898090286 cites W2288486409 @default.
• W2898090286 cites W2292920864 @default.
• W2898090286 cites W2341041396 @default.
• W2898090286 cites W2346372208 @default.
• W2898090286 cites W2402331667 @default.
• W2898090286 cites W2473139211 @default.
• W2898090286 cites W2509505498 @default.
• W2898090286 cites W2520891743 @default.
• W2898090286 cites W2529259446 @default.
• W2898090286 cites W2530222662 @default.
• W2898090286 cites W2572109366 @default.
• W2898090286 cites W2589625654 @default.
• W2898090286 cites W2605685784 @default.
• W2898090286 cites W2765280737 @default.
• W2898090286 cites W2767416879 @default.
• W2898090286 cites W2775093110 @default.
• W2898090286 cites W2780598835 @default.
• W2898090286 cites W4210981518 @default.
• W2898090286 doi "https://doi.org/10.1371/journal.pone.0206093" @default.
• W2898090286 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6201926" @default.
• W2898090286 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30359409" @default.
• W2898090286 hasPublicationYear "2018" @default.
• W2898090286 type Work @default.
• W2898090286 sameAs 2898090286 @default.
• W2898090286 citedByCount "45" @default.
• W2898090286 countsByYear W28980902862019 @default.
• W2898090286 countsByYear W28980902862020 @default.
• W2898090286 countsByYear W28980902862021 @default.
• W2898090286 countsByYear W28980902862022 @default.
• W2898090286 countsByYear W28980902862023 @default.
• W2898090286 crossrefType "journal-article" @default.
• W2898090286 hasAuthorship W2898090286A5007864114 @default.
• W2898090286 hasAuthorship W2898090286A5027202045 @default.
• W2898090286 hasAuthorship W2898090286A5034769845 @default.
• W2898090286 hasAuthorship W2898090286A5036491309 @default.
• W2898090286 hasAuthorship W2898090286A5050716556 @default.
• W2898090286 hasAuthorship W2898090286A5053677600 @default.
• W2898090286 hasAuthorship W2898090286A5056075180 @default.
• W2898090286 hasAuthorship W2898090286A5063028605 @default.
• W2898090286 hasAuthorship W2898090286A5068395602 @default.
• W2898090286 hasAuthorship W2898090286A5076663213 @default.
• W2898090286 hasAuthorship W2898090286A5087872155 @default.
• W2898090286 hasAuthorship W2898090286A5090272472 @default.
• W2898090286 hasBestOaLocation W28980902861 @default.
• W2898090286 hasConcept C164027704 @default.
• W2898090286 hasConcept C203014093 @default.
• W2898090286 hasConcept C2522874641 @default.
• W2898090286 hasConcept C2776914184 @default.

• next