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- W2898090552 abstract "Gastrulation is a key milestone in early mouse development when multipotent epiblast cells are allocated to progenitors of diverse tissue lineages that constitute the ensemble of building blocks of the body plan. The analysis of gene function revealed that the activity of transcription factors is likely to be the fundamental driving force underpinning the lineage specification and tissue patterning in the primary germ layers. The developmental‐spatial transcriptome of the gastrulating embryo revealed the concerted and interactive activity of the gene regulatory network anchored by development‐related transcription factors. The findings of the network structure offer novel insights into the regionalization of tissue fates and enable tracking of the progression of epiblast patterning, leading to the construction of molecularly annotated fate maps of epiblast during gastrulation." @default.
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- W2898090552 date "2018-10-01" @default.
- W2898090552 modified "2023-10-18" @default.
- W2898090552 title "Mouse gastrulation: Attributes of transcription factor regulatory network for epiblast patterning" @default.
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- W2898090552 doi "https://doi.org/10.1111/dgd.12568" @default.
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