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• W2898092447 abstract "Alcohol abuse synergistically heightens the development of the third most deadliest cancer hepatocellular carcinoma (HCC) in patients infected with hepatitis C virus (HCV). Ectopically expressed TLR4 promotes liver tumorigenesis in alcohol-fed HCV Ns5a or Core transgenic mice. CD133+/CD49f + tumor-initiating stem cell-like cells (TICs) isolated from these models are tumorigenic have p53 degradation via phosphorylation of the protective protein NUMB and its dissociation from p53 by the oncoprotein TBC1D15. Nutrient deprivation reduces overexpressed TBC1D15 in TICs via autophagy-mediated degradation, suggesting a possible role of this oncoprotein in linking metabolic reprogramming and self-renewal." @default.
• W2898092447 created "2018-11-02" @default.
• W2898092447 creator A5070288633 @default.
• W2898092447 date "2018-01-01" @default.
• W2898092447 modified "2023-10-15" @default.
• W2898092447 title "NANOG-Dependent Metabolic Reprogramming and Symmetric Division in Tumor-Initiating Stem-like Cells" @default.
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• W2898092447 doi "https://doi.org/10.1007/978-3-319-98788-0_8" @default.
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