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- W2898094943 abstract "The identification of malignancy of solitary pulmonary nodule (SPN) is important for lung cancer eraly detection. Carcinogenesis may result from accumulation of molecular evolution and escaping from host immunoediting. However, the immune landscape such as T cell repertoire of benign and malignant SPNs have not been systemically studied. We have collected resected solitary pulmonary nodules (SPNs) and peripheral blood including benign SPNs (N=10), LUSC (N=11) and LUAD (N=38) from 59 patients. T cell repertoire of infiltrating T cells in SPNs were sequenced their T cell receptor b genes (TCRb) , as well as their abundance in peripheral blood. Enrichment clonotypes were defined as 500 fold enrichment as compared to blood. Comparison to the peripheral blood, T cell repertoire diversity of infiltrating T cells in SPNs showed significant differences among benign and malignant. T cell clonality was higher in the benign SPNs than Malignant, however no significant differences among LUSC and LUAD. Additionally, we observed that Tumors from smokers had higher T cell clonality than no-smokers as reported earlier. Interestingly, many T cell clones, including major clones, were shared between lung tissues and matched peripheral blood; furthermore, the higher shared clonotypes of T cell clones between lung tissues and blood in benign SPNs than Malignant. Enrichment analysis demonstrated more enriched clonotypes observed in LUSC and LUAD. Our preliminary data demonstrate the distinct immune microenvironment in SPNs may be associated with the benign and malignant features. And implies a significant proportion of infiltrating T cells in SPNs may be a function of constant lung infiltrating rather than an anti-tumor response." @default.
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- W2898094943 date "2018-10-01" @default.
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- W2898094943 title "P1.03-11 Analysis of T-Cell Repertoires in Benign and Malignant Solitary Pulmonary Nodules to Evaluate Tumor Immune Microenviroment" @default.
- W2898094943 doi "https://doi.org/10.1016/j.jtho.2018.08.692" @default.
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