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- W2898096429 abstract "Abstract The innate immune system helps animals to navigate the microbial world. The response to microbes relies on the specific recognition of microbial-associated molecular patterns (MAMPs) by immune receptors. Sponges (phylum Porifera), as early-diverging animals, provide insights into conserved mechanisms for animal-microbe crosstalk. However, experimental data is limited. We adopted an experimental approach followed by RNA-Seq and differential gene expression analysis in order to characterise the sponge immune response. Two Mediterranean species, Aplysina aerophoba and Dysidea avara , were exposed to a “cocktail” of MAMPs (lipopolysaccharide and peptidoglycan) or to sterile artificial seawater (control) and sampled 1 h, 3 h, and 5 h post-treatment for RNA-Seq. The response involved, first and foremost, a higher number of differentially-expressed genes in A . aerophoba than D . avara . Secondly, while both species constitutively express a diverse repertoire of immune receptors, they differed in their expression profiles upon MAMP challenge. The response in D . avara was mediated by increased expression of two NLR genes, whereas the response in A . aerophoba involved SRCR and GPCR genes. From the set of annotated genes we infer that both species activated apoptosis in response to MAMPs while in A . aerophoba phagocytosis was additionally stimulated. Our study assessed for the first time the transcriptomic responses of sponges to MAMPs and revealed conserved and species-specific features of poriferan immunity as well as genes potentially relevant to animal-microbe interactions." @default.
- W2898096429 created "2018-11-02" @default.
- W2898096429 creator A5006776492 @default.
- W2898096429 creator A5024806867 @default.
- W2898096429 creator A5045630538 @default.
- W2898096429 creator A5046169109 @default.
- W2898096429 date "2018-10-31" @default.
- W2898096429 modified "2023-10-05" @default.
- W2898096429 title "Differential expression of immune receptors in two marine sponges upon exposure to microbial-associated molecular patterns" @default.
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- W2898096429 doi "https://doi.org/10.1038/s41598-018-34330-w" @default.
- W2898096429 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6208332" @default.
- W2898096429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30382170" @default.
- W2898096429 hasPublicationYear "2018" @default.
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